A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma

Blessborn, DanielHögskolan Dalarna,Kemiteknik,Dalarna University College, S-781 88 Borlänge, Sweden (author)

A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator, The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.

NATURVETENSKAP Kemi hsv//swe
NATURAL SCIENCES Chemical Sciences hsv//eng
antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stability

Neamin, G.Dalarna University College, S-781 88 Borlänge, Sweden (author)
Bergqvist, YngveHögskolan Dalarna,Kemiteknik,Dalarna University College, S-781 88 Borlänge, Sweden(Swepub:du)ybq (author)
Lindegårdh, N.Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, UK (author)
Högskolan DalarnaKemiteknik (creator_code:org_t)

In:Journal of Pharmaceutical and Biomedical Analysis: Elsevier BV41:1, s. 207-2120731-70851873-264X

By the author/editor: Blessborn, Danie ...; Neamin, G.; Bergqvist, Yngve; Lindegårdh, N.

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