Accelerated radiotherapy for advanced laryngeal cancer.

• The purpose of this study was to evaluate a single institution's outcome for patients with advanced laryngeal cancer treated with accelerated radiotherapy (RT). Fifty-eight patients with advanced laryngeal cancer (T3/T4N0/N + M0) were treated with curative intent with accelerated RT during the period 1990-1998. Patients received radiotherapy alone or with induction chemotherapy. The 5-year local control (LC) and loco-regional control (LRC) probabilities were both 49% for T3 and 75% for T4 tumors. The 5-year disease-free survival probability was 46% and 68% and overall survival probability was 30% and 39% for T3 and T4 tumors respectively. No significant statistical difference in outcome was found, either between T3 and T4 tumors, or between patients who received induction chemotherapy and those who did not. The treatment results for advanced laryngeal cancer at this institution were comparable to those reported in the literature. The results for T3 and T4 were similar. T4 classification alone should not be an exclusion criterion for larynx preservation. Overall survival was poor, partly because of a high incidence of deaths from intercurrent diseases.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adult

Aged

Aged

80 and over

Antineoplastic Agents

administration & dosage

adverse effects

Antineoplastic Combined Chemotherapy Protocols

therapeutic use

Carcinoma

Squamous Cell

pathology

radiotherapy

Cisplatin

administration & dosage

adverse effects

Disease-Free Survival

Female

Fluorouracil

administration & dosage

adverse effects

Follow-Up Studies

Humans

Laryngeal Neoplasms

pathology

radiotherapy

Male

Middle Aged

Neoplasm Recurrence

Local

prevention & control

Neoplasm Regression

Spontaneous

Neoplasm Staging

Radiotherapy

methods

Retrospective Studies

Treatment Outcome

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