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Stereotactic body r...
Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer - a first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study.
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- Baumann, Pia (author)
- Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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- Nyman, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Hoyer, Morten (author)
- Divisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark
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- Gagliardi, Giovanna (author)
- Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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- Lax, Ingmar (author)
- Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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- Wennberg, Berit (author)
- Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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- Drugge, Ninni (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Ekberg, Lars (author)
- Divisions of Oncology, Hospital Physics, Malmö University Hospital, Sweden
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- Friesland, Signe (author)
- Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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- Johansson, Karl-Axel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
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Lund, Jo-Smund (author)
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- Morhed, Elisabeth (author)
- Department of Oncology and Radiotherapy, Akademiska University Hospital, Uppsala, Sweden
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- Nilsson, Kristina (author)
- Uppsala universitet,Enheten för onkologi,Department of Oncology and Radiotherapy, Akademiska University Hospital, Uppsala, Sweden
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- Levin, Nina (author)
- Department of Oncology, Trondheim University Hospital, Norway
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- Paludan, Merete (author)
- Divisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark
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- Sederholm, Christer (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Lungmedicin,Lungmedicinska kliniken US
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- Traberg, Anders (author)
- Divisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark
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- Wittgren, Lena (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Divisions of Oncology, Hospital Physics, Malmö University Hospital, Sweden
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- Lewensohn, Rolf (author)
- Karolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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- Lund, JA (author)
- Lund, J.-Å., Department of Oncology, Trondheim University Hospital, Norway
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 88:3, s. 359-67
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Abstract
Subject headings
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- BACKGROUND AND AIMS: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15Gyx3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardio vascular disease (CVD). MATERIAL AND METHODS: Sixty patients were entered in the study between August 2003 and September 2005. Fifty-seven patients (T1 65%, T2 35%) with a median age of 75 years (59-87 years) were evaluable. The baseline mean FEV1% was 64% and median Karnofsky index was 80. A total dose of 45Gy was delivered in three fractions at the 67% isodose of the PTV. Clinical, pulmonary and radiological evaluations were made at 6 weeks, 3, 6, 9, 12, 18, and 36 months post-SBRT. Toxicity was graded according to CTC v2.0 and performance status was graded according to the Karnofsky scale. RESULTS: At a median follow-up of 23 months, 2 patients had relapsed locally. No grade 4 or 5 toxicity was reported. Grade 3 toxicity was seen in 12 patients (21%). There was no significant decline of FEV1% during follow-up. Low grade pneumonitis developed to the same extent in the CVD 3/17 (18%) and COPD 7/40 (18%) groups. The incidence of fibrosis was 9/17 (53%) and pleural effusions was 8/17 (47%) in the CVD group compared with 13/40 (33%) and 5/40 (13%) in the COPD group. CONCLUSION: SBRT for stage I NSCLC patients who are medically inoperable because of COPD and CVD results in a favourable local control rate with a low incidence of grade 3 and no grade 4 or 5 toxicity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Aged
- Aged
- 80 and over
- Carcinoma
- Non-Small-Cell Lung
- pathology
- physiopathology
- radiotherapy
- Cardiovascular Diseases
- complications
- Chi-Square Distribution
- Dose Fractionation
- Female
- Humans
- Lung Neoplasms
- pathology
- physiopathology
- radiotherapy
- Male
- Middle Aged
- Neoplasm Staging
- Prospective Studies
- Pulmonary Disease
- Chronic Obstructive
- complications
- Radiosurgery
- methods
- Radiotherapy Dosage
- Respiratory Function Tests
- Retrospective Studies
- Treatment Outcome
- COPD
- SBRT
- Inoperable stage I NSCLC
- CVD
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Baumann, Pia
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Nyman, Jan, 1956
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Hoyer, Morten
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Gagliardi, Giova ...
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Lax, Ingmar
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Wennberg, Berit
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show more...
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Drugge, Ninni
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Ekberg, Lars
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Friesland, Signe
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Johansson, Karl- ...
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Lund, Jo-Smund
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Morhed, Elisabet ...
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Nilsson, Kristin ...
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Levin, Nina
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Paludan, Merete
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Sederholm, Chris ...
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Traberg, Anders
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Wittgren, Lena
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Lewensohn, Rolf
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Lund, JA
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Radiotherapy and ...
- By the university
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University of Gothenburg
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Lund University
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Uppsala University
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Karolinska Institutet
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Linköping University