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Stereotactic body r...
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Baumann, PiaKarolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
(author)
Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer - a first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study.
- Article/chapterEnglish2008
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Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/100357
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https://gup.ub.gu.se/publication/100357URI
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https://doi.org/10.1016/j.radonc.2008.07.019DOI
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https://lup.lub.lu.se/record/1284130URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105474URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117783253URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50265URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND AND AIMS: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15Gyx3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardio vascular disease (CVD). MATERIAL AND METHODS: Sixty patients were entered in the study between August 2003 and September 2005. Fifty-seven patients (T1 65%, T2 35%) with a median age of 75 years (59-87 years) were evaluable. The baseline mean FEV1% was 64% and median Karnofsky index was 80. A total dose of 45Gy was delivered in three fractions at the 67% isodose of the PTV. Clinical, pulmonary and radiological evaluations were made at 6 weeks, 3, 6, 9, 12, 18, and 36 months post-SBRT. Toxicity was graded according to CTC v2.0 and performance status was graded according to the Karnofsky scale. RESULTS: At a median follow-up of 23 months, 2 patients had relapsed locally. No grade 4 or 5 toxicity was reported. Grade 3 toxicity was seen in 12 patients (21%). There was no significant decline of FEV1% during follow-up. Low grade pneumonitis developed to the same extent in the CVD 3/17 (18%) and COPD 7/40 (18%) groups. The incidence of fibrosis was 9/17 (53%) and pleural effusions was 8/17 (47%) in the CVD group compared with 13/40 (33%) and 5/40 (13%) in the COPD group. CONCLUSION: SBRT for stage I NSCLC patients who are medically inoperable because of COPD and CVD results in a favourable local control rate with a low incidence of grade 3 and no grade 4 or 5 toxicity.
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Nyman, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xnymja
(author)
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Hoyer, MortenDivisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark
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Gagliardi, GiovannaKarolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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Lax, IngmarKarolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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Wennberg, BeritKarolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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Drugge, NinniGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
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Ekberg, LarsDivisions of Oncology, Hospital Physics, Malmö University Hospital, Sweden
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Friesland, SigneKarolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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Johansson, Karl-AxelGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
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Lund, Jo-Smund
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Morhed, ElisabethDepartment of Oncology and Radiotherapy, Akademiska University Hospital, Uppsala, Sweden
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Nilsson, KristinaUppsala universitet,Enheten för onkologi,Department of Oncology and Radiotherapy, Akademiska University Hospital, Uppsala, Sweden(Swepub:uu)kristnil
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Levin, NinaDepartment of Oncology, Trondheim University Hospital, Norway
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Paludan, MereteDivisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark
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Sederholm, ChristerÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Lungmedicin,Lungmedicinska kliniken US(Swepub:liu)chrse81
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Traberg, AndersDivisions of Oncology and Medical Physics, Aarhus University Hospital, Denmark
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Wittgren, LenaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Divisions of Oncology, Hospital Physics, Malmö University Hospital, Sweden(Swepub:lu)rfa-lwi
(author)
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Lewensohn, RolfKarolinska Institutet,Divisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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Lund, JALund, J.-Å., Department of Oncology, Trondheim University Hospital, Norway
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Karolinska InstitutetDivisions of Oncology, Hospital Physics, Radiumhemment, Sweden
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In:Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology: Elsevier BV88:3, s. 359-670167-81401879-0887
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Baumann, Pia
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Nyman, Jan, 1956
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Hoyer, Morten
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Gagliardi, Giova ...
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Lax, Ingmar
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Wennberg, Berit
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Drugge, Ninni
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Ekberg, Lars
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Friesland, Signe
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Johansson, Karl- ...
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Lund, Jo-Smund
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Morhed, Elisabet ...
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Nilsson, Kristin ...
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Levin, Nina
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Paludan, Merete
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Sederholm, Chris ...
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Traberg, Anders
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Wittgren, Lena
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Lewensohn, Rolf
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Lund, JA
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University of Gothenburg
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