Sökning: WFRF:(Hentschke P) >
Mixed chimaerism is...
Mixed chimaerism is common at the time of acute graft-versus-host disease and disease response in patients receiving non-myeloablative conditioning and allogeneic stem cell transplantation.
-
- Mattsson, Jonas, 1966 (författare)
- Karolinska Institutet
-
- Uzunel, M (författare)
- Karolinska Institutet
-
- Brune, Mats, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
-
visa fler...
-
Hentschke, P (författare)
-
Barkholt, L (författare)
-
- Stierner, Ulrika, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
-
Aschan, J (författare)
-
- Ringdén, O (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Wiley, 2001
- 2001
- Engelska.
-
Ingår i: British journal of haematology. - : Wiley. - 0007-1048. ; 115:4, s. 935-44
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We report the clinical outcome and results of chimaerism analysis in various cell lineages of 30 patients given non-myeloablative conditioning, followed by allogeneic stem cell transplantation (SCT). The commonest diagnoses were chronic myelogenous leukaemia (n = 11) and solid tumours (n = 11). Twenty-one patients received SCT from human leucocyte antigen (HLA)-identical siblings and nine from matched unrelated donors. Median patient age was 53 (28-77) years. Four non-myeloablative protocols were used, including fludarabine (30 mg/m2 x 3-6), busulphan (4 mg/kg x 2), cyclophosphamide (Cy) (30 mg/kg/day x 2) or total body irradiation (2 Gy), and anti-thymocyte globulin. The patients were analysed by polymerase chain reaction (PCR) analysis of minisatellites on days 14, 21 and 28, then every other week up to 3 months and monthly thereafter. All samples were cell separated for T, B and myeloid cells using immunomagnetic beads. Eighteen patients were alive at a median follow-up of 11 (6-20) months. Acute graft-versus-host disease (GVHD) occurred in 22 patients. Eighteen of the 22 patients with acute GVHD showed mixed chimaerism (MC) in the T-cell fraction at the time of acute GVHD. However, all patients with acute GVHD showed donor chimaerism (DC) in the T-cell fraction median 76 (7-414) days after onset versus three out of eight patients without acute GVHD, P < 0.001]. Disease response was diagnosed in 15 patients, median 100 (37-531) days after SCT. At the time of disease response, six out of 15 patients showed MC in the T-cell fraction. In conclusion, mixed chimaerism in the T-cell fraction is common at the time of acute GVHD and disease response in patients conditioned with non-myeloablative therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Bone Marrow Cells
- pathology
- Busulfan
- therapeutic use
- Cell Count
- Cyclophosphamide
- therapeutic use
- Female
- Graft vs Host Disease
- immunology
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing
- Humans
- Immunosuppressive Agents
- therapeutic use
- Male
- Middle Aged
- T-Lymphocytes
- pathology
- Transplantation Conditioning
- methods
- Transplantation
- Homologous
- Treatment Outcome
- Vidarabine
- analogs & derivatives
- therapeutic use
- Whole-Body Irradiation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mattsson, Jonas, ...
-
Uzunel, M
-
Brune, Mats, 195 ...
-
Hentschke, P
-
Barkholt, L
-
Stierner, Ulrika ...
-
visa fler...
-
Aschan, J
-
Ringdén, O
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
British journal ...
- Av lärosätet
-
Göteborgs universitet
-
Karolinska Institutet