UVB irradiation induces melanocyte increase in both exposed and shielded human skin.

Stierner, Ulrika,1952Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine (author)

This study demonstrates for the first time in humans that UV light induces an increase of the melanocyte population in exposed skin as well as in shielded areas. Because an increased mitotic activity could promote tumor development, UV exposure might play a role in melanoma development not only in exposed but also in covered skin. In addition, it was found that subjects who initially had a small melanocyte population showed a larger increase in both exposed and covered skin compared to those with a high initial density. Individuals with a low density might therefore constitute a risk group for the development of malignant melanoma. These findings support the view that infrequent periods of intensive UV irradiation might be more harmful than regular exposure.

Rosdahl, Inger,1943Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine (author)
Augustsson, AGothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine (author)
Kågedal, B (author)
Göteborgs universitetMedicinska institutionen (creator_code:org_t)

By the author/editor: Stierner, Ulrika ...; Rosdahl, Inger, ...; Augustsson, A; Kågedal, B

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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