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On the relation bet...
On the relation between capsaicin sensitivity and responsiveness to CO2: detection sensitivity and event-related brain potentials.
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- Andersson, Linus, 1979- (författare)
- Umeå universitet,Institutionen för psykologi
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- Nordin, Steven, 1960- (författare)
- Umeå universitet,Institutionen för psykologi
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- Millqvist, Eva, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Sahlgrenska University Hospital Asthma and Allergy Research Group Göteborg, Sweden
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- Bende, Mats, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar,Institute of Clinical Sciences, Department of Otorhinolaryngology,Central Hospital Department of Otorhinolaryngology Skövde Sweden
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(creator_code:org_t)
- 2008-05-14
- 2009
- Engelska.
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Ingår i: International archives of occupational and environmental health. - : Springer Science and Business Media LLC. - 1432-1246 .- 0340-0131. ; 82:3, s. 285-90
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Sensory hyperreactivity (SHR) with predominantly airway symptoms is a subgroup of chemical intolerance to various environmental substances with pungent/odorous properties. The hallmark of SHR is sensitivity to capsaicin inhalation, resulting in extensive coughing likely to be mediated by a C-fiber hyperreactivity of the airway sensory neurons. However, it is not clear whether capsaicin sensitivity implies a greater sensitivity to chemosomatosensory substances in general. Therefore, the present study tested the hypothesis of an association between capsaicin cough sensitivity and sensitivity to CO(2) with respect to detection sensitivity and electrophysiological brain response. METHODS: A correlational study was employed to investigate the relation between capsaicin cough sensitivity and detection thresholds and chemosomatosensory event-related potentials (ERPs) for CO(2) presented in the nasal cavity in 35 persons varying in capsaicin cough sensitivity. RESULTS: Number of coughs were found to correlate negatively with CO(2) threshold and tended to correlate negatively also with N1 and P2 latencies of the chemosomatosensory ERP for CO(2). No tendencies of correlations were found between number of coughs and latencies for olfactory and auditory ERPs, recorded for comparison, but, unexpectedly, were found between number of coughs and auditory N1 amplitude. CONCLUSIONS: The results imply that capsaicin cough sensitivity, such as in SHR, is related to higher detection sensitivity, and tends to be related to faster cortical processing of other chemosomatosensory substances, at least of CO(2).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Administration
- Inhalation
- Adult
- Bronchial Hyperreactivity
- chemically induced
- diagnosis
- physiopathology
- Capsaicin
- diagnostic use
- Carbon Dioxide
- pharmacology
- Cough
- chemically induced
- physiopathology
- Drug Hypersensitivity
- diagnosis
- etiology
- physiopathology
- Evoked Potentials
- Somatosensory
- drug effects
- physiology
- Female
- Humans
- Male
- Middle Aged
- Multiple Chemical Sensitivity
- diagnosis
- etiology
- physiopathology
- Olfactory Pathways
- drug effects
- physiopathology
- Pentanols
- pharmacology
- Sensory Thresholds
- drug effects
- physiology
- Young Adult
- Chemosomatosensory
- Psychology
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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