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Immunoreactivity ag...
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Ardesjö, BritaUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
(författare)
Immunoreactivity against Goblet cells in patients with inflammatory bowel disease.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Oxford University Press (OUP),2008
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/101416
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https://gup.ub.gu.se/publication/101416URI
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https://doi.org/10.1002/ibd.20370DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97134URI
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: A number of autoantibodies have been reported in inflammatory bowel disease (IBD). The aim of this study was to investigate to what extent sera from patients with IBD contain autoantibodies directed against normal human gastrointestinal mucosa. METHODS: Samples of sera from 50 patients with IBD and 50 healthy subjects were used for immunostaining of normal and affected human gastrointestinal tissues. RESULTS: Eighty-four percent of the sera from IBD patients showed immunoreactivity against goblet cells in the appendix compared with 8% of the sera from healthy subjects. Goblet cell reactivity of IBD patient sera varied between regions in the gastrointestinal tract. Sera from healthy subjects only reacted with goblet cells in the appendix. In the colon and the appendix, goblet cell reactivity of IBD sera was generally weak at the base of the crypts and gradually increased toward the lumen. Three IBD sera samples reacted with gastrin cells in the antrum. In colon biopsies from patients with ulcerative colitis, immunoreactivity against the remaining goblet cells showed an inverse correlation with inflammatory activity. CONCLUSIONS: These findings suggest that immunoreactivity against goblet cells may be of central importance in the pathogenesis of IBD. Identification of goblet cell antigens could lead to a better understanding of IBD and provide a new diagnostic tool.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
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Adult
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Aged
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Antibodies
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blood
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immunology
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Appendix
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immunology
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metabolism
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pathology
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Biopsy
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Colitis
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Ulcerative
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immunology
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metabolism
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pathology
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Colon
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immunology
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metabolism
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pathology
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Crohn Disease
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immunology
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metabolism
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pathology
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Duodenum
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immunology
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metabolism
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pathology
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Endoscopy
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Gastrointestinal
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Female
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Goblet Cells
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immunology
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pathology
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Humans
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Immunity
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Cellular
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immunology
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Immunohistochemistry
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Inflammatory Bowel Diseases
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immunology
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metabolism
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pathology
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Male
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Microscopy
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Fluorescence
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Middle Aged
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Pyloric Antrum
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immunology
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metabolism
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pathology
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Severity of Illness Index
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inflammatory bowel disease
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MEDICINE
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Portela-Gomes, Guida MUppsala universitet,Institutionen för genetik och patologi
(författare)
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Rorsman, FredrikUppsala universitet,Institutionen för medicinska vetenskaper,magtarm(Swepub:uu)fredrikr
(författare)
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Gerdin, EvaUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)evagerdi
(författare)
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Lööf, LarsUppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)larsloof
(författare)
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Grimelius, LarsUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)larsgrim
(författare)
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Kämpe, OlleUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)(Swepub:uu)ollekamp
(författare)
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Ekwall, Olov,1968Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)(Swepub:uu)olovekwa
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Inflammatory bowel diseases: Oxford University Press (OUP)14:5, s. 652-611078-09981536-4844
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