Self-assembled monolayer coating for normalization of surface enhanced Raman spectra

• We demonstrate that the use of a self-assembled monolayer, consisting of a thiol derivative of Dabcyl, can be used to normalize surface enhanced Raman signals (SERS) with respect to varying enhancement. Chaotic assemblies of gold nanoparticles exhibit large spatial variation in enhancement. Our work shows that in such a system the signals from the reporting molecules in the SAM co-vary with the signal from the analyte solution. With this knowledge, a normalization procedure was used to increase the precision of the analyte signal by 1 order of magnitude, to 8-13%, fully acceptable for quantitative work.

Subject headings

NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Keyword

self-assembled monolayer

SAM

surface enhanced Raman spectrocopy

SERS

normalization

principal components analysis

PCA

gold nanoparticle

normalization

Publication and Content Type

ref (subject category)

art (subject category)