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Gender role behavio...
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Frisén, LarsKarolinska Institutet
(författare)
Gender role behavior, sexuality, and psychosocial adaptation in women with congenital adrenal hyperplasia due to CYP21A2 deficiency
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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The Endocrine Society,2009
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/102897
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https://gup.ub.gu.se/publication/102897URI
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https://doi.org/10.1210/jc.2009-0636DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119311604URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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CONTEXT: Gender-atypical behavior has been described in young girls as well as in women with congenital adrenal hyperplasia (CAH) due to a CYP21A2 deficiency. OBJECTIVE: The aim of the study was to assess health-related, psychosexual, and psychosocial parameters and correlate the results to CYP21A2 genotype. DESIGN AND PARTICIPANTS: Sixty-two Swedish women with CAH and age-matched controls completed a 120-item questionnaire and a validated quality of life instrument [psychological general well-being (PGWB) formula] to identify psychosexual and psychosocial parameters. The patients were divided into four CYP21A2 genotype groups. RESULTS: The women with CAH held more male-dominant occupations (30%) compared to controls (13%) (P = 0.04), especially those in the null genotype group (55%) (P = 0.006). They also reported a greater interest in rough sports (74%) compared to controls (50%) (P = 0.007). Eight women with CAH (14%) reported a prime interest in motor vehicles, compared to none of the controls (P = 0.002). Non-heterosexual orientation was reported by 19% of women with CAH (P = 0.005), 50% in the null genotype group (P = 0.0001), 30% in I2 splice (NS), and 5% in I172N (NS). PGWB total score did not differ between patients and controls. CONCLUSION: We identified increased gender-atypical behavior in women with CAH that could be correlated to the CYP21A2 genotype. This speaks in favor of dose-dependent effects of prenatal androgens on the development of higher brain functions. The impact of the disease on upbringing and interpersonal relationships did not correlate with disease severity, indicating that other factors, such as coping strategies, are important for psychosocial adaptation. This illustrates the need for psychological support to parents and patients.
Ämnesord och genrebeteckningar
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*Adaptation
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Psychological
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Adolescent
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Adrenal Hyperplasia
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Congenital/*psychology
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Adult
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Female
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*Gender Identity
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Genotype
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Humans
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Middle Aged
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Quality of Life
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*Sexuality
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Steroid 21-Hydroxylase/genetics
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nordenström, AnnaKarolinska Institutet
(författare)
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Falhammar, HenrikKarolinska Institutet
(författare)
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Filipsson, Helena,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xfilih
(författare)
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Holmdahl, Gundela,1956Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xhogun
(författare)
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Janson, Per-Olof,1940Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xjperm
(författare)
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Thoren, MarjaKarolinska Institutet
(författare)
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Hagenfeldt, KerstinKarolinska Institutet
(författare)
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Möller, Anders,1947Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xmolla
(författare)
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Nordenskjöld, AgnetaKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:J Clin Endocrinol Metab: The Endocrine Society94:9, s. 3432-9
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Ingår i:The Journal of Clinical Endocrinology & Metabolism: The Endocrine Society94:9, s. 3432-90021-972X1945-7197
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Göteborgs universitet
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Karolinska Institutet