Morphological appearance and chemical composition of enamel in primary teeth from patients with 22q11 deletion syndrome.

• Patients with 22q11 deletion syndrome have many and complex medical problems, including hypocalcemia and/or hypoparathyroidism. Odontological findings include enamel aberrations in both dentitions. In order to describe enamel morphology, chemical composition in primary teeth, and to investigate the relationship between medical history and morphological appearance, dental enamel was investigated in 38 exfoliated primary teeth from 15 children and adolescents. Morphology was studied by the use of a polarized light microscope, microradiography, scanning electron microscopy, X-ray microanalysis, and secondary ion mass spectrometry. The morphological findings were compared with medical history. The teeth showed, in principle, a normal morphological appearance with regard to prism structure. A high frequency of aberrations, such as hypomineralization, hypoplasia and extra incremental lines, were found. The majority of the aberrations were found around the neonatal line. There was a relationship between high numbers of medical problems in the patients and enamel deviations. The result supports the hypothesis of under-reporting of both hypocalcemia and hypoparathyroidism in patients with 22q11 deletion syndrome.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

Adolescent

Adult

Child

Child

Preschool

Chromosome Deletion

Chromosomes

Human

Pair 22

genetics

Dental Enamel

abnormalities

chemistry

Female

Humans

Hypocalcemia

complications

genetics

Hypothyroidism

complications

genetics

Male

Severity of Illness Index

Syndrome

Tooth Abnormalities

complications

genetics

Tooth

Deciduous

chemistry

pathology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)