Sökning: WFRF:(Eliasson M) >
One-year treatment ...
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Bunck, M. C.
(författare)
One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/103058
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https://gup.ub.gu.se/publication/103058URI
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE: Traditional blood glucose-lowering agents do not sustain adequate glycemic control in most type 2 diabetic patients. Preclinical studies with exenatide have suggested sustained improvements in beta-cell function. We investigated the effects of 52 weeks of treatment with exenatide or insulin glargine followed by an off-drug period on hyperglycemic clamp-derived measures of beta-cell function, glycemic control, and body weight. RESEARCH DESIGN AND METHODS: Sixty-nine metformin-treated patients with type 2 diabetes were randomly assigned to exenatide (n = 36) or insulin glargine (n = 33). beta-Cell function was measured during an arginine-stimulated hyperglycemic clamp at week 0, at week 52, and after a 4-week off-drug period. Additional end points included effects on glycemic control, body weight, and safety. RESULTS: Treatment-induced change in combined glucose- and arginine-stimulated C-peptide secretion was 2.46-fold (95% CI 2.09-2.90, P < 0.0001) greater after a 52-week exenatide treatment compared with insulin glargine treatment. Both exenatide and insulin glargine reduced A1C similarly: -0.8 +/- 0.1 and -0.7 +/- 0.2%, respectively (P = 0.55). Exenatide reduced body weight compared with insulin glargine (difference -4.6 kg, P < 0.0001). beta-Cell function measures returned to pretreatment values in both groups after a 4-week off-drug period. A1C and body weight rose to pretreatment values 12 weeks after discontinuation of either exenatide or insulin glargine therapy. CONCLUSIONS: Exenatide significantly improves beta-cell function during 1 year of treatment compared with titrated insulin glargine. After cessation of both exenatide and insulin glargine therapy, beta-cell function and glycemic control returned to pretreatment values, suggesting that ongoing treatment is necessary to maintain the beneficial effects of either therapy.
Ämnesord och genrebeteckningar
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Arginine/pharmacology
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Blood Glucose/metabolism
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Body Mass Index
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C-Peptide/blood
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Diabetes Mellitus
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Type 2/blood/*drug therapy/physiopathology
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Female
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Hemoglobin A
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Glycosylated/metabolism
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Humans
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Hypoglycemic Agents/*therapeutic use
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Insulin/*analogs & derivatives/*secretion/therapeutic use
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Insulin-Secreting Cells/drug effects/*physiology
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Kinetics
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Male
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Metformin/*therapeutic use
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Middle Aged
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Peptides/*therapeutic use
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Venoms/*therapeutic use
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Diamant, M.
(författare)
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Corner, A.
(författare)
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Eliasson, Björn,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xelibj
(författare)
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Malloy, J. L.
(författare)
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Shaginian, R. M.
(författare)
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Deng, W.
(författare)
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Kendall, D. M.
(författare)
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Taskinen, M. R.
(författare)
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Smith, Ulf,1943Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmiul
(författare)
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Yki-Jarvinen, H.
(författare)
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Heine, R. J.
(författare)
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Göteborgs universitetInstitutionen för medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes Care32:5, s. 762-81935-5548
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Bunck, M. C.
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Diamant, M.
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Corner, A.
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Eliasson, Björn, ...
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Malloy, J. L.
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Shaginian, R. M.
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visa fler...
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Deng, W.
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Kendall, D. M.
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Taskinen, M. R.
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Smith, Ulf, 1943
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Yki-Jarvinen, H.
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Heine, R. J.
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visa färre...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Göteborgs universitet