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Low molecular weigh...
Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro
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- Ekman-Ordeberg, G (author)
- Karolinska Institutet
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- Hellgren, Margareta, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Åkerud, Anna (author)
- Karolinska Institutet,Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups
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Andersson, E (author)
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Dubicke, A (author)
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- Sennstrom, M. (author)
- Karolinska Institutet
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- Byström, B (author)
- Karolinska Institutet
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- Tzortzatos, G (author)
- Karolinska Institutet
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- Gomez, Maria (author)
- Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups
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- Edlund, M. (author)
- Karolinska Institutet
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- Lindahl, Ulf (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Malmström, Anders (author)
- Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: Acta Obstet Gynecol Scand. - : Wiley. ; 88:9, s. 984-989
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Abstract
Subject headings
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- OBJECTIVES: The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical ripening and if the anticoagulative activity is necessary for its effect. DESIGN: Experimental in vitro study. SETTING: Lund University and Karolinska Institute, Sweden. METHODS: The effect of low molecular weight heparins with or without anticoagulative properties on myometrial contractility was measured in vitro on smooth muscle strips from biopsies obtained at elective cesarean sections. The effects on cervical ripening were assessed in cervical fibroblasts cultured from explants of cervical biopsies obtained at delivery. MAIN OUTCOME MEASURES: Mean force and number of contractions in uterine smooth muscle strips and interleukin-8 (IL-8) secretion in cervical fibroblasts. RESULTS: Myometrial smooth muscle strips pretreated with low molecular weight heparins showed increased contractile activity compared to untreated smooth muscle strips. Secretion of IL-8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin. Both these effects were independent of anticoagulative activity of the low molecular weight heparin. CONCLUSIONS: A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL-8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo. Our data support the notion that anticoagulant activity is not required to promote labor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Adult
- Anticoagulants/*pharmacology
- Cell Culture Techniques
- Cervical Ripening/drug effects
- Cervix Uteri/*drug effects/metabolism/*pathology
- Dalteparin/*pharmacology
- Female
- Fibroblasts/*drug effects
- Humans
- Interleukin-8/metabolism
- Pregnancy
- Tissue Culture Techniques
- Uterine Contraction/*drug effects
- Low molecular weight heparin
- cervical ripening
- myometrial
- contractility
- Low molecular weight heparin
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ekman-Ordeberg, ...
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Hellgren, Margar ...
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Åkerud, Anna
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Andersson, E
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Dubicke, A
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Sennstrom, M.
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show more...
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Byström, B
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Tzortzatos, G
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Gomez, Maria
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Edlund, M.
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Lindahl, Ulf
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Malmström, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
- Acta Obstet Gyne ...
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Acta Obstetricia ...
- By the university
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University of Gothenburg
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Lund University
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Uppsala University
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Karolinska Institutet