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  • Carlsson, BeatriceLinköpings universitet,Molekylär virologi,Hälsouniversitetet (author)

The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection. : Novel GII.4 disease pattern

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-05-18
  • Public Library of Science (PLoS),2009

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/103574
  • https://gup.ub.gu.se/publication/103574URI
  • https://doi.org/10.1371/journal.pone.0005593DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18974URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Original Publication: Beatrice Carlsson, Elin Kindberg, Javier Buesa, Gustaf E Rydell, Marta Fos Lidón, Rebeca Montava, Reem Abu Mallouh, Ammi Grahn, Jesús Rodríguez-Díaz, Juan Bellido, Alberto Arnedo, Göran Larson and Lennart Svensson, The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection., 2009, PLoS ONE, (4), 5, e5593. http://dx.doi.org/10.1371/journal.pone.0005593 Licensed under Creative Commons
  • In November 2004, 116 individuals in an elderly nursing home in El Grao de Castellón, Spain were symptomatically infected with genogroup II.4 (GII.4) norovirus. The global attack rate was 54.2%. Genotyping of 34 symptomatic individuals regarding the FUT2 gene revealed that one patient was, surprisingly, a non-secretor, hence indicating secretor-independent infection. Lewis genotyping revealed that Lewis-positive and negative individuals were susceptible to symptomatic norovirus infection indicating that Lewis status did not predict susceptibility. Saliva based ELISA assays were used to determine binding of the outbreak virus to saliva samples. Saliva from a secretor-negative individual bound the authentic outbreak GII.4 Valencia/2004/Es virus, but did not in contrast to secretor-positive saliva bind VLP of other strains including the GII.4 Dijon strain. Amino acid comparison of antigenic A and B sites located on the external loops of the P2 domain revealed distinct differences between the Valencia/2004/Es and Dijon strains. All three aa in each antigenic site as well as 10/11 recently identified evolutionary hot spots, were unique in the Valencia/2004/Es strain compared to the Dijon strain. To the best of our knowledge, this is the first example of symptomatic GII.4 norovirus infection of a Le(a+b-) individual homozygous for the G428A nonsense mutation in FUT2. Taken together, our study provides new insights into the host genetic susceptibility to norovirus infections and evolution of the globally dominating GII.4 viruses.

Subject headings and genre

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  • Kindberg, ElinLinköpings universitet,Molekylär virologi,Hälsouniversitetet(Swepub:liu)eliki64 (author)
  • Buesa, JavierUniversity of Valencia (author)
  • Rydell, Gustaf EGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrenska University Hospital(Swepub:gu)xrydeg (author)
  • Lidón, Marta FosUniversity of Valencia (author)
  • Montava, RebecaUniversity of Valencia (author)
  • Abu Mallouh, ReemUniversity of Valencia (author)
  • Grahn, Ammi,1961Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrenska University Hospital(Swepub:gu)xgraam (author)
  • Rodríguez-Díaz, JesúsUniversity of Valencia (author)
  • Bellido, JuanCentro de Salud Pública (author)
  • Arnedo, AlbertoCentro de Salud Pública (author)
  • Larson, Göran,1953Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Sahlgrenska University Hospital(Swepub:gu)xlarsg (author)
  • Svensson, LennartLinköpings universitet,Molekylär virologi,Hälsouniversitetet(Swepub:liu)lensv66 (author)
  • Linköpings universitetMolekylär virologi (creator_code:org_t)

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  • In:PloS one: Public Library of Science (PLoS)4:51932-6203

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