T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.

Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine (author)

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
Blood Platelets
immunology
physiology
Case-Control Studies
Cytotoxicity
Immunologic
genetics
Granzymes
Humans
Interferon-gamma
genetics
Membrane Glycoproteins
genetics
Oligonucleotide Array Sequence Analysis
Perforin
Pore Forming Cytotoxic Proteins
Purpura
Thrombocytopenic
Idiopathic
blood
genetics
immunology
Receptors
Immunologic
genetics
Receptors
Interleukin-2
genetics
Receptors
KIR
Serine Endopeptidases
genetics
T-Lymphocytes
Cytotoxic
immunology
physiology

Andersson, Per-Ola,1964Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xapert (author)
Jernås, Margareta,1961Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xjernm (author)
Jacobsson, Stefan,1951Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xjacst (author)
Carlsson, Björn,1958Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xcarbj (author)
Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xcarle (author)
Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xwadha (author)
Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin (creator_code:org_t)

In:Nature medicine: Springer Science and Business Media LLC9:9, s. 1123-41078-89561546-170X

By the author/editor: Olsson, Bob, 196 ...; Andersson, Per-O ...; Jernås, Margaret ...; Jacobsson, Stefa ...; Carlsson, Björn, ...; Carlsson, Lena M ...; show more...; Wadenvik, Hans, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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