Search: WFRF:(Prieto Prieto J.)
> (2005-2009) >
Glomerular type 1 a...
Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
-
Crowley, S. D. (author)
-
Vasievich, M. P. (author)
-
Ruiz, P. (author)
-
show more...
-
Gould, S. K. (author)
-
Parsons, K. K. (author)
-
Pazmino, A. K. (author)
-
Facemire, C. (author)
-
Chen, B. J. (author)
-
Kim, H. S. (author)
-
Tran, T. T. (author)
-
Pisetsky, D. S. (author)
-
Barisoni, L. (author)
-
Prieto-Carrasquero, M. C. (author)
-
- Jeansson, Marie, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
-
Foster, M. H. (author)
-
Coffman, T. M. (author)
-
show less...
-
(creator_code:org_t)
- 2009
- 2009
- English.
-
In: J Clin Invest. - 1558-8238 .- 1558-8238 .- 0021-9738. ; 119:4, s. 943-53
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Studies in humans and animal models indicate a key contribution of angiotensin II to the pathogenesis of glomerular diseases. To examine the role of type 1 angiotensin (AT1) receptors in glomerular inflammation associated with autoimmune disease, we generated MRL-Faslpr/lpr (lpr) mice lacking the major murine type 1 angiotensin receptor (AT1A); lpr mice develop a generalized autoimmune disease with glomerulonephritis that resembles SLE. Surprisingly, AT1A deficiency was not protective against disease but instead substantially accelerated mortality, proteinuria, and kidney pathology. Increased disease severity was not a direct effect of immune cells, since transplantation of AT1A-deficient bone marrow did not affect survival. Moreover, autoimmune injury in extrarenal tissues, including skin, heart, and joints, was unaffected by AT1A deficiency. In murine systems, there is a second type 1 angiotensin receptor isoform, AT1B, and its expression is especially prominent in the renal glomerulus within podocytes. Further, expression of renin was enhanced in kidneys of AT1A-deficient lpr mice, and they showed evidence of exaggerated AT1B receptor activation, including substantially increased podocyte injury and expression of inflammatory mediators. Administration of losartan, which blocks all type 1 angiotensin receptors, reduced markers of kidney disease, including proteinuria, glomerular pathology, and cytokine mRNA expression. Since AT1A-deficient lpr mice had low blood pressure, these findings suggest that activation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and inflammation in the absence of hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Animals
- Autoimmune Diseases/*etiology/immunology/pathology/physiopathology
- Chemokines/genetics
- Cytokines/genetics
- Female
- Kidney/injuries/pathology/physiopathology
- Male
- Mice
- Mice
- Inbred MRL lpr
- Mice
- Knockout
- Nephritis/*etiology/immunology/pathology/physiopathology
- RNA
- Messenger/genetics/metabolism
- Receptor
- Angiotensin
- Type 1/deficiency/genetics/*physiology
- Renin-Angiotensin System/physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Crowley, S. D.
-
Vasievich, M. P.
-
Ruiz, P.
-
Gould, S. K.
-
Parsons, K. K.
-
Pazmino, A. K.
-
show more...
-
Facemire, C.
-
Chen, B. J.
-
Kim, H. S.
-
Tran, T. T.
-
Pisetsky, D. S.
-
Barisoni, L.
-
Prieto-Carrasque ...
-
Jeansson, Marie, ...
-
Foster, M. H.
-
Coffman, T. M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
J Clin Invest
- By the university
-
University of Gothenburg
-
Uppsala University