Sökning: WFRF:(Sjölund Kristina) > CRIM1 is localized ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05616naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/104974 | |
003 | SwePub | |
008 | 240528s2009 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:2b2194b6-312f-418f-adcc-fd1a9d95beda | |
009 | oai:prod.swepub.kib.ki.se:118977926 | |
024 | 7 | a https://gup.ub.gu.se/publication/1049742 URI |
024 | 7 | a https://lup.lub.lu.se/record/12886362 URI |
024 | 7 | a https://doi.org/10.1093/ndt/gfn7432 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1189779262 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nyström, Jenny,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xnysje |
245 | 1 0 | a CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney |
264 | 1 | b Oxford University Press (OUP),c 2009 |
520 | a BACKGROUND: CRIM1 is a plasma membrane bound protein containing six cysteine-rich repeats (CRR). Through these, CRIM1 has been shown to interact with a subgroup of the TGF-beta superfamily, the bone morphogenic proteins (BMP) isoforms 2, 4 and 7. The probable action is to modulate the signalling properties of these factors. CRIM1 has also been shown to regulate the release of VEGFA by podocytes during renal organogenesis. Knock-out studies in mice have shown that CRIM1 is critically involved in the development of the central nervous system, eye and kidney. Replacement of CRIM1 with a defective version leads to renal dysgenesis and perinatal death. We have analysed the distribution of CRIM1 in adult human renal tissue. METHODS: To this end, we have used immunofluorescence, immunohistochemistry and immunoelectron microscopy. We performed western blotting for the CRIM1 protein, using lysates from isolated glomerular podocytes and human renal tissue homogenate. By using quantitative PCR, we compared the CRIM1 mRNA levels in podocytes, human renal tissue homogenate, primary human renal proximal tubular epithelial cells and primary human pulmonary artery smooth muscle cells. RESULTS: The results show that in the human adult kidney, CRIM1 is mainly expressed in the glomerular podocytes and is associated with the insertional region of the filtration slit diaphragm (SD) of the podocyte pedicles. CONCLUSIONS: CRIM1 is a protein that should be added to the list of proteins associated with the podocyte filtration SD and with the probable action of modulating BMP and VEGFA signalling. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a Adult | |
653 | a Cells | |
653 | a Cultured | |
653 | a Humans | |
653 | a Kidney/*chemistry | |
653 | a Membrane Proteins/*analysis | |
653 | a Podocytes/*chemistry | |
653 | a podocyte | |
653 | a immunoelectron microscopy | |
653 | a bone morphogenic protein | |
653 | a filtration slit membrane | |
700 | 1 | a Hultenby, K.u Karolinska Institutet4 aut |
700 | 1 | a Ek, Sarau Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-san |
700 | 1 | a Sjölund, Jonasu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-sjo |
700 | 1 | a Axelson, Håkanu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-hax |
700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji |
700 | 1 | a Saleem, M. A.4 aut |
700 | 1 | a Nilsson, Kristinau Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-kn0 |
700 | 1 | a Johansson, Martinu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-mim |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t Nephrol Dial Transplantd : Oxford University Press (OUP)g 24:7, s. 2038-44q 24:7<2038-44x 1460-2385x 1460-2385x 0931-0509 |
856 | 4 | u http://dx.doi.org/10.1093/ndt/gfn743x freey FULLTEXT |
856 | 4 | u https://academic.oup.com/ndt/article-pdf/24/7/2038/12806623/gfn743.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/104974 |
856 | 4 8 | u https://lup.lub.lu.se/record/1288636 |
856 | 4 8 | u https://doi.org/10.1093/ndt/gfn743 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118977926 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy