The cytoskeleton in fish melanophore melanosome positioning.

Nilsson Sköld, Helen,1970Gothenburg University,Göteborgs universitet,Zoologiska institutionen, zoofysiologi,Department of Zoology, Zoophysiology (author)

Melanophore melanosomes organelles can be regulated to move and locate correspondingly to many other different organelle types. Comparing lessons from analysis of a specific melanosome distribution can, therefore, contribute to the understanding of distribution of other organelles, and vice versa. From such data, it is now generally accepted that microtubules provide directed long-distance movement, while cell peripheral movements include microfilaments. In fish melanophores, both actin and dynein exhibit counter-forces to the kinesin-like protein in maintaining the evenly dispersed state, while actin and kinesin exhibit counter-forces to dynein in many other systems. Lessons from elevating cAMP levels indicate the presence of a peripheral feedback regulatory system involved in maintaining the evenly dispersed state. Studies from dynein inhibition suggest that the kinesin-like protein involved in fish melanosome dispersal is regulated in contrast to many other systems. One would further expect melanosome transport to be regulated also on actin/myosin, in order to prevent actin-dependent capture of melanosomes during the microtubule-dependent aggregation and dispersion. General findings will be discussed in comparison with positioning and movement of other organelle types in cells. Finally, recent data on melanosome-dependent organising of microtubules show that dynein is involved in nucleating microtubules extending from melanosome aggregates in melanophore fragments.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
NATURVETENSKAP Biologi Ekologi hsv//swe
NATURAL SCIENCES Biological Sciences Ecology hsv//eng
Animals
Biological Transport
Cytoskeleton
physiology
Fishes
anatomy & histology
physiology
Melanophores
physiology
ultrastructure
Melanosomes
physiology
ultrastructure
Microscopy
Electron

Aspengren, Sara,1977Gothenburg University,Göteborgs universitet,Zoologiska institutionen, zoofysiologi,Department of Zoology, Zoophysiology(Swepub:gu)xaspsa (author)
Wallin, Margareta,1952Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology(Swepub:gu)xwmars (author)
Göteborgs universitetZoologiska institutionen, zoofysiologi (creator_code:org_t)

By the author/editor: Nilsson Sköld, H ...; Aspengren, Sara, ...; Wallin, Margaret ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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