Search: WFRF:(West Chris)
> (2009) >
Effects of family h...
-
Hayden, Kathleen M
(author)
Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
-
American Medical Association (AMA),2009
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/105812
-
https://gup.ub.gu.se/publication/105812URI
-
https://doi.org/10.1001/archneurol.2009.237DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
OBJECTIVE: To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline. DESIGN, SETTING, AND PARTICIPANTS: Residents of Cache County, Utah, aged 65 years or older, were invited to participate. At baseline, 2957 participants provided DNA for genotyping of APOE and a detailed FHxAD. They also completed the Modified Mini-Mental State Examination. Cognitive status was reexamined after 3 and 7 years. We used mixed-effects models to examine the association among FHxAD, APOE epsilon4, and cognitive trajectories. MAIN OUTCOME MEASURE: Modified Mini-Mental State Examination score trajectories over time. RESULTS: Compared with participants who did not have APOE epsilon4 or an FHxAD, those with APOE epsilon4 scored lower on the Modified Mini-Mental State Examination at baseline (-0.70 points; 95% confidence interval [CI], -1.15 to -0.24). Participants with an FHxAD and APOE epsilon4 differed less, if at all, in baseline score (-0.46 points; 95% CI, -1.09 to 0.16) but declined faster during the 7-year study (-9.75 points [95% CI, -10.82 to -8.67] vs -2.91 points [95% CI, -3.37 to -2.44]). After exclusion of participants who developed prodromal AD or incident dementia, the group with an FHxAD and APOE epsilon4 declined much less during the 7-year study (-1.54; 95% CI, -2.59 to -0.50). CONCLUSIONS: Much of the association among FHxAD, APOE epsilon4, and cognitive decline may be attributed to undetected incipient (latent) disease. In the absence of latent disease, the 2 factors do not appear individually to be associated with cognitive decline, although they may be additive.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Zandi, Peter P
(author)
-
West, Nancy A
(author)
-
Tschanz, Joann T
(author)
-
Norton, Maria C
(author)
-
Corcoran, Chris
(author)
-
Breitner, John C S
(author)
-
Welsh-Bohmer, Kathleen A
(author)
-
Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xskooi
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:Archives of neurology: American Medical Association (AMA)66:11, s. 1378-831538-36870003-9942
Internet link
Find in a library
To the university's database
- By the author/editor
-
Hayden, Kathleen ...
-
Zandi, Peter P
-
West, Nancy A
-
Tschanz, Joann T
-
Norton, Maria C
-
Corcoran, Chris
-
show more...
-
Breitner, John C ...
-
Welsh-Bohmer, Ka ...
-
Skoog, Ingmar, 1 ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Archives of neur ...
- By the university
-
University of Gothenburg