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  • Nordström, Anna,1973-Umeå universitet,Idrottsmedicin (author)

Interleukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women.

  • Article/chapterEnglish2004

Publisher, publication year, extent ...

  • 2004-03-02
  • Springer Science and Business Media LLC,2004

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/106109
  • https://gup.ub.gu.se/publication/106109URI
  • https://doi.org/10.1007/s00198-004-1610-9DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-69839URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16901URI
  • https://lup.lub.lu.se/record/898367URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Interleukin 6 (IL-6) is a multifunctional cytokine and a potent stimulator of bone resorption and has been implicated in the pathogenesis of osteoporosis in postmenopausal women. The aim of this study was to investigate if a functional IL-6 promoter polymorphism (-174) was related to bone mass and fractures in a cohort consisting of 964 postmenopausal Caucasian women aged 75 years. Bone mineral density (BMD; g/cm2) of the femoral neck, lumbar spine and total body was measured using dual energy X-ray absorptiometry (DXA). Quantitative ultrasound (QUS) was also measured in the calcaneus and quantified as speed of sound (SOS; m/s), broadband ultrasound attenuation (BUA; dB/MHz), and stiffness index (SI). IL-6 genotypes was determined by restriction fragment length polymorphism (RFLP) using the restriction enzyme NlaIII. The frequencies of the different IL-6 genotypes were 27.5% (GG), 47.9% (GC), 24.6% (CC). The IL-6 polymorphism (presence of G) was independently related to a lower stiffness (beta=-0.07; P=0.03) and BUA (beta=-0.08; P=0.02), but not to BMD at any site measured by DXA. In the cohort, 420 subjects (44%) reported at least one fracture during their lifetime, and 349 (36%) reported at least one fracture after the age of 50. Using binary logistic regression, the IL-6 polymorphism (presence of G) was significantly related to an increased risk of a previous fracture during life (odds ratio 1.46, 95% CI 1.08-1.97) and to an increased risk of a fracture occurring after 50 years of age (odds ratio 1.37, 95% CI 1.004-1.88). The risk was further increased for fractures grouped as osteoporotic fractures (odds ratio 1.67, 95% CI 1.14-2.45), including forearm fractures (odds ratio 1.59, 95% CI 1.05-2.40). In conclusion, presence of G allele in the IL-6 promoter polymorphism at position -174 is independently related to previous fractures in postmenopausal women. This association may be related primarily to an altered bone quality identified by QUS and not a lower bone mass. This is also the first demonstration of association of IL-6 gene polymorphism to calcaneal QUS.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gerdhem, PaulLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-pge (author)
  • Brändström, HelenaUppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Sweden(Swepub:uu)helebran (author)
  • Stiger, FredrikUppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Sweden(Swepub:uu)fredstig (author)
  • Lerner, Ulf HUmeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,Oral cellbiologi(Swepub:umu)ulle0001 (author)
  • Lorentzon, Mattias,1970Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,Idrottsmedicin(Swepub:gu)xlomat (author)
  • Obrant, KarlLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-kob (author)
  • Nordström, PeterUmeå universitet,Geriatrik,Idrottsmedicin(Swepub:umu)peno0014 (author)
  • Åkesson, KristinaLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-kak (author)
  • Umeå universitetIdrottsmedicin (creator_code:org_t)

Related titles

  • In:Osteoporosis international: Springer Science and Business Media LLC15:10, s. 820-60937-941X1433-2965

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