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Interleukin-6 promo...
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Nordström, Anna,1973-Umeå universitet,Idrottsmedicin
(author)
Interleukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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2004-03-02
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Springer Science and Business Media LLC,2004
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/106109
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https://gup.ub.gu.se/publication/106109URI
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https://doi.org/10.1007/s00198-004-1610-9DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-69839URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16901URI
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https://lup.lub.lu.se/record/898367URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Interleukin 6 (IL-6) is a multifunctional cytokine and a potent stimulator of bone resorption and has been implicated in the pathogenesis of osteoporosis in postmenopausal women. The aim of this study was to investigate if a functional IL-6 promoter polymorphism (-174) was related to bone mass and fractures in a cohort consisting of 964 postmenopausal Caucasian women aged 75 years. Bone mineral density (BMD; g/cm2) of the femoral neck, lumbar spine and total body was measured using dual energy X-ray absorptiometry (DXA). Quantitative ultrasound (QUS) was also measured in the calcaneus and quantified as speed of sound (SOS; m/s), broadband ultrasound attenuation (BUA; dB/MHz), and stiffness index (SI). IL-6 genotypes was determined by restriction fragment length polymorphism (RFLP) using the restriction enzyme NlaIII. The frequencies of the different IL-6 genotypes were 27.5% (GG), 47.9% (GC), 24.6% (CC). The IL-6 polymorphism (presence of G) was independently related to a lower stiffness (beta=-0.07; P=0.03) and BUA (beta=-0.08; P=0.02), but not to BMD at any site measured by DXA. In the cohort, 420 subjects (44%) reported at least one fracture during their lifetime, and 349 (36%) reported at least one fracture after the age of 50. Using binary logistic regression, the IL-6 polymorphism (presence of G) was significantly related to an increased risk of a previous fracture during life (odds ratio 1.46, 95% CI 1.08-1.97) and to an increased risk of a fracture occurring after 50 years of age (odds ratio 1.37, 95% CI 1.004-1.88). The risk was further increased for fractures grouped as osteoporotic fractures (odds ratio 1.67, 95% CI 1.14-2.45), including forearm fractures (odds ratio 1.59, 95% CI 1.05-2.40). In conclusion, presence of G allele in the IL-6 promoter polymorphism at position -174 is independently related to previous fractures in postmenopausal women. This association may be related primarily to an altered bone quality identified by QUS and not a lower bone mass. This is also the first demonstration of association of IL-6 gene polymorphism to calcaneal QUS.
Subject headings and genre
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Gerdhem, PaulLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-pge
(author)
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Brändström, HelenaUppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Sweden(Swepub:uu)helebran
(author)
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Stiger, FredrikUppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Sweden(Swepub:uu)fredstig
(author)
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Lerner, Ulf HUmeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,Oral cellbiologi(Swepub:umu)ulle0001
(author)
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Lorentzon, Mattias,1970Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,Idrottsmedicin(Swepub:gu)xlomat
(author)
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Obrant, KarlLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-kob
(author)
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Nordström, PeterUmeå universitet,Geriatrik,Idrottsmedicin(Swepub:umu)peno0014
(author)
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Åkesson, KristinaLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-kak
(author)
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Umeå universitetIdrottsmedicin
(creator_code:org_t)
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In:Osteoporosis international: Springer Science and Business Media LLC15:10, s. 820-60937-941X1433-2965
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