Search: (WFRF:(Willemsen Gonneke)) pers:(De Geus Eco J. C.) pers:(Rivadeneira Fernando) >
A genome-wide assoc...
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-07-01
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Oxford University Press (OUP),2009
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/106208
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https://gup.ub.gu.se/publication/106208URI
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https://doi.org/10.1093/hmg/ddp296DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (P(combined) = 3.4 x 10(-9)). Notably, a second SNP (rs6718438) located approximately 450 bp away and in strong LD (r(2) = 0.77) with rs6717918 was previously found to be suggestive of a height association in 29 820 individuals of mainly northwestern European ancestry, and the over-expression of a nearby natriuretic peptide precursor type C (NPPC) gene, has been associated with overgrowth and skeletal anomalies. We also found a SNP (rs10472828) located on 5p14 near the natriuretic peptide receptor 3 (NPR3) gene, encoding a receptor of the NPPC ligand, to be associated with body height (P(combined) = 2.1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height.
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Krawczak, Michael
(author)
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Schreiber, Stefan
(author)
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van Duijn, Kate
(author)
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Stolk, Lisette
(author)
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van Meurs, Joyce B J
(author)
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Liu, Fan
(author)
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Penninx, Brenda W J H
(author)
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Smit, Jan H
(author)
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Vogelzangs, Nicole
(author)
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Hottenga, Jouke Jan
(author)
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Willemsen, Gonneke
(author)
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de Geus, Eco J C
(author)
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xlomat
(author)
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von Eller-Eberstein, Huberta
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Lips, Paul
(author)
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Schoor, Natascha
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Pop, Victor
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de Keijzer, Jules
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Hofman, Albert
(author)
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Aulchenko, Yurii S
(author)
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Oostra, Ben A
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl
(author)
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Boomsma, Dorret I
(author)
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Uitterlinden, Andre G
(author)
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van Duijn, Cornelia M
(author)
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Rivadeneira, Fernando
(author)
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Kayser, Manfred
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
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In:Human molecular genetics: Oxford University Press (OUP)18:18, s. 3516-241460-20830964-6906
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van Duijn, Kate
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Liu, Fan
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de Geus, Eco J C
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Lorentzon, Matti ...
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von Eller-Eberst ...
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Lips, Paul
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Schoor, Natascha
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Pop, Victor
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de Keijzer, Jule ...
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Hofman, Albert
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Aulchenko, Yurii ...
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Oostra, Ben A
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Uitterlinden, An ...
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