id:"swepub:oai:gup.ub.gu.se/106633"
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- Renström, FridaUmeå universitet,Medicin (författare)
Factors in serum from type 2 diabetes patients can cause cellular insulin resistance
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
- Georg Thieme Verlag KG,2009
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/106633
- https://gup.ub.gu.se/publication/106633URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32396URI
- https://doi.org/10.1055/s-0029-1220751DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211245URI
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- Språk:engelska
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- SwePubSwePub
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Anmärkningar
- This pilot study was aimed to investigate whether there are humoral factors in serum from type 2 diabetic subjects that, in addition to glucose, insulin and free fatty acids are able to induce or contribute to peripheral insulin resistance with respect to glucose transport. Isolated subcutaneous adipocytes from 11 type 2 diabetic subjects and 10 nondiabetic controls were incubated for 24-h in medium supplemented with 25 % serum from a control or a type 2 diabetic donor, in the presence of a low (5 mM) or a high (15 mM) glucose concentration, respectively. After the incubation period glucose uptake capacity was assessed. Serum from type 2 diabetic donors, compared to serum from controls, significantly reduced the maximal insulin eff ect to stimulate glucose uptake (approximately 40 %, p < 0.05) in adipocytes from control subjects, independent of surrounding glucose concentrations. Glucose uptake capacity in adipocytes isolated from type 2 diabetic subjects was similar regardless of culture condition. No significant alterations were found in cellular content of key proteins in the insulin signaling cascade (insulin receptor substrate-1 and -2, and glucose transporter 4) that could explain the impaired insulin-stimulated glucose transport in control adipocytes incubated with serum from type 2 diabetic donors. The present findings indicate the presence of biomolecules in the circulation of type 2 diabetic subjects, apart from glucose, insulin, and free fatty acids with the ability to induce peripheral insulin resistance. This further implies that even though normoglycemia is achieved other circulating factors can still negatively aff ect insulin sensitivity in type 2 diabetic patients.
Ämnesord och genrebeteckningar
- Adipocytes
- Adult
- Biological Transport/*physiology
- Diabetes Mellitus
- Type 2/*metabolism
- Fatty Acids
- Nonesterified/blood
- Female
- Glucose Transporter Type 4/blood
- Humans
- Insulin Receptor Substrate Proteins/blood
- Insulin Resistance/*physiology
- Male
- Middle Aged
- Pilot Projects
- Statistics
- Nonparametric
- glucose transport
- MEDICINE
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Burén, JonasUmeå universitet,Medicin(Swepub:umu)jobu0003 (författare)
- Svensson, M.K,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmara (författare)
- Eriksson, Jan W,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:uu)janer909 (författare)
- Umeå universitetMedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Horm Metab Res: Georg Thieme Verlag KG41:10, s. 767-721439-42861439-42860018-5043
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- Renström, Frida
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- Horm Metab Res
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- Göteborgs universitet
- Umeå universitet
- Uppsala universitet
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