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Oral rivaroxaban fo...
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Eriksson, Bengt I.,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
(författare)
Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement
- Artikel/kapitelEngelska2009
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Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/107017
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https://gup.ub.gu.se/publication/107017URI
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https://doi.org/10.1302/0301-620X.91B5.21691DOI
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Ämneskategori:art swepub-publicationtype
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A once-daily dose of rivaroxaban 10 mg, an oral, direct Factor Xa inhibitor, was compared with enoxaparin 40 mg subcutaneously once daily for prevention of venous thromboembolism in three studies of patients undergoing elective hip and knee replacement (RECORD programme). A pooled analysis of data from these studies (n = 9581) showed that rivaroxaban was more effective than enoxaparin in reducing the incidence of the composite of symptomatic venous thromboembolism and all-cause mortality at two weeks (0.4% vs 0.8%, respectively, odds ratio 0.44; 95% confidence interval 0.23 to 0.79; p = 0.005), and at the end of the planned medication period (0.5% vs 1.3%, respectively; odds ratio 0.38; 95% confidence interval 0.22 to 0.62; p < 0.001). The rate of major bleeding was similar at two weeks (0.2% for both) and at the end of the planned medication period (0.3% vs 0.2%). Rivaroxaban started six to eight hours after surgery was more effective than enoxaparin started the previous evening in preventing symptomatic venous thromboembolism and all-cause mortality, without increasing major bleeding.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
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Administration
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Oral
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Adolescent
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Adult
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Aged
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Aged
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80 and over
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Anticoagulants/*administration & dosage
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Arthroplasty
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Replacement/*adverse effects/mortality
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Arthroplasty
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Replacement
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Hip/adverse effects/mortality
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Arthroplasty
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Replacement
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Knee/adverse effects/mortality
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Double-Blind Method
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Drug Administration Schedule
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Enoxaparin/*administration & dosage
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Factor Xa/*antagonists & inhibitors
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Female
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Humans
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Male
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Middle Aged
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Morpholines/*administration & dosage
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Thiophenes/*administration & dosage
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Treatment Outcome
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Venous Thromboembolism/*prevention & control
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Young Adult
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kakkar, A. K.
(författare)
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Turpie, A. G.
(författare)
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Gent, M.
(författare)
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Bandel, T. J.
(författare)
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Homering, M.
(författare)
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Misselwitz, F.
(författare)
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Lassen, M. R.
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Bone and Joint Surgery91:5, s. 636-440301-620X
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