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Oral rivaroxaban fo...
Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement
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- Eriksson, Bengt I., 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Kakkar, A. K. (author)
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Turpie, A. G. (author)
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Gent, M. (author)
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Bandel, T. J. (author)
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Homering, M. (author)
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Misselwitz, F. (author)
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Lassen, M. R. (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Journal of Bone and Joint Surgery. - 0301-620X. ; 91:5, s. 636-44
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A once-daily dose of rivaroxaban 10 mg, an oral, direct Factor Xa inhibitor, was compared with enoxaparin 40 mg subcutaneously once daily for prevention of venous thromboembolism in three studies of patients undergoing elective hip and knee replacement (RECORD programme). A pooled analysis of data from these studies (n = 9581) showed that rivaroxaban was more effective than enoxaparin in reducing the incidence of the composite of symptomatic venous thromboembolism and all-cause mortality at two weeks (0.4% vs 0.8%, respectively, odds ratio 0.44; 95% confidence interval 0.23 to 0.79; p = 0.005), and at the end of the planned medication period (0.5% vs 1.3%, respectively; odds ratio 0.38; 95% confidence interval 0.22 to 0.62; p < 0.001). The rate of major bleeding was similar at two weeks (0.2% for both) and at the end of the planned medication period (0.3% vs 0.2%). Rivaroxaban started six to eight hours after surgery was more effective than enoxaparin started the previous evening in preventing symptomatic venous thromboembolism and all-cause mortality, without increasing major bleeding.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Administration
- Oral
- Adolescent
- Adult
- Aged
- Aged
- 80 and over
- Anticoagulants/*administration & dosage
- Arthroplasty
- Replacement/*adverse effects/mortality
- Arthroplasty
- Replacement
- Hip/adverse effects/mortality
- Arthroplasty
- Replacement
- Knee/adverse effects/mortality
- Double-Blind Method
- Drug Administration Schedule
- Enoxaparin/*administration & dosage
- Factor Xa/*antagonists & inhibitors
- Female
- Humans
- Male
- Middle Aged
- Morpholines/*administration & dosage
- Thiophenes/*administration & dosage
- Treatment Outcome
- Venous Thromboembolism/*prevention & control
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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