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Circulating lung-cancer-related non-coding RNAs are associated with occupational exposure to hexavalent chromium - A cross-sectional study within the SafeChrom project
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- Jiang, Zheshun (författare)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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- Person, Romane (författare)
- Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.;Univ Paris Cite, INSERM UMR S 1139, Paris, France.;Univ Paris Cite, UMR S 1139, Paris, France.,Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; INSERM UMR-S 1124 and UMR-S 1139, Université Paris Cité, Paris, France
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- Lundh, Thomas (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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- SafeChrom Project Team, - (bidragsgivare)
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- (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
- Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 190
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: Hexavalent chromium (Cr(VI)) is classified as a group 1 human carcinogen and increases the risk of lung cancer. Non-coding RNAs (ncRNAs) have key regulatory roles in lung cancer, but less is known about their relation to Cr(VI) exposure.Objectives: We aimed to 1) measure the expression of lung cancer-related circulating ncRNAs in exposed workers and controls; 2) assess associations between ncRNAs expression and Cr concentrations in red blood cells (RBC) and urine; and 3) evaluate correlations between the ncRNAs.Methods: The study included 111 Cr(VI) exposed workers and 72 controls recruited from the SafeChrom project. Cr concentrations were measured in RBC (biomarker of long-term exposure) and urine (biomarker of short-term exposure) samples. Long ncRNA (lncRNA) and microRNA (miRNA) were extracted from plasma followed by deoxyribonuclease treatment, complementary DNA synthesis, and quantitative real-time polymerase chain reaction using target-specific assays for three lncRNAs (H19, MALAT1, NORAD), and four miRNAs (miR-142-3p, miR-15b-5p, miR-3940-5p, miR-451a).Results: Expression levels of lncRNAs MALAT1 and NORAD, and all four miRNAs, were significantly lower in Cr (VI) exposed workers compared with controls, and correlated significantly with RBC-Cr concentrations (rS = -0.16 to -0.38). H19 was non-significantly increased in exposed workers but significantly correlated with miR142-3p (rS = -0.33) and miR-15b-5p (rS = -0.30), and NORAD was significantly positively correlated with all four miRNAs (rS = 0.17 to 0.46). In multivariate regression models adjusting for confounders, expressions of lncRNAs MALAT1 and NORAD and all miRNAs were still significantly lower in the exposed group compared with controls, and the expression decreased with increasing RBC-Cr concentrations. Conclusions: Cr(VI) exposure was inversely and in a dose-response manner associated with the expression of circulating non-coding RNA, which suggests ncRNAs as potential biomarkers for Cr(VI)-induced toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Hexavalent chromium
- miRNA
- lncRNA
- RBC chromium
- Biomarkers
- Lung cancer
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- art (ämneskategori)
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- Jiang, Zheshun
- Person, Romane
- Lundh, Thomas
- Pineda, Daniela
- Engfeldt, Malin
- Krais, Annette M
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