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Circulating lung-ca...
Circulating lung-cancer-related non-coding RNAs are associated with occupational exposure to hexavalent chromium - A cross-sectional study within the SafeChrom project
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- Jiang, Zheshun (författare)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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- Person, Romane (författare)
- Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.;Univ Paris Cite, INSERM UMR S 1139, Paris, France.;Univ Paris Cite, UMR S 1139, Paris, France.,Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; INSERM UMR-S 1124 and UMR-S 1139, Université Paris Cité, Paris, France
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- Lundh, Thomas (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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visa fler...
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- Pineda, Daniela (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Applied Mass Spectrometry in Environmental Medicine,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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- Engfeldt, Malin (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Genetisk arbets- och miljömedicin,Other operations, LTH,Faculty of Engineering, LTH,Occupational and Environmental Dermatology,Lund University Research Groups,Genetic Occupational and Environmental Medicine,Region Skåne,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.;Reg Skane, Occupat & Environm Med, Lund, Sweden.
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- Krais, Annette M (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Centrum för hälsosamma inomhusmiljöer, CHIE,Annan verksamhet, LTH,Lunds Tekniska Högskola,LTH profilområde: Aerosoler,LTH profilområden,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups,Centre for Healthy Indoor Environments,Other operations, LTH,Faculty of Engineering, LTH,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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- Hagberg, Jessika, 1974- (författare)
- Örebro University,Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro Univ, Fac Business Sci & Engn, Dept Occupat & Environm Hlth, Örebro, Sweden.
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- Ricklund, Niklas, 1979- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Health,Örebro Univ, Fac Med & Hlth, Dept Occupat & Environm Hlth, Örebro, Sweden.
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- Vogel, Ulla (författare)
- Natl Res Ctr Working Environm, Copenhagen, Denmark.,National Research Centre for the Working Environment, Copenhagen, Denmark
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- Saber, Anne T. (författare)
- Natl Res Ctr Working Environm, Copenhagen, Denmark.,National Research Centre for the Working Environment, Copenhagen, Denmark
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- Tondel, Martin (författare)
- Uppsala University,Uppsala universitet,Arbets- och miljömedicin,Uppsala Univ Hosp, Occupat & Environm Med, Uppsala, Sweden.,Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Occupational and Environmental Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Albin, Maria (författare)
- Karolinska Institute,Lund University,Lunds universitet,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Environmental Epidemiology,Lund University Research Groups,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Broberg, Karin (författare)
- Karolinska Institute,Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LTH profilområde: Aerosoler,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,The National Research Centre for the Working Environment,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.;Natl Res Ctr Working Environm, Copenhagen, Denmark.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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SafeChrom Project Team, - (bidragsgivare)
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 190
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Hexavalent chromium (Cr(VI)) is classified as a group 1 human carcinogen and increases the risk of lung cancer. Non-coding RNAs (ncRNAs) have key regulatory roles in lung cancer, but less is known about their relation to Cr(VI) exposure.Objectives: We aimed to 1) measure the expression of lung cancer-related circulating ncRNAs in exposed workers and controls; 2) assess associations between ncRNAs expression and Cr concentrations in red blood cells (RBC) and urine; and 3) evaluate correlations between the ncRNAs.Methods: The study included 111 Cr(VI) exposed workers and 72 controls recruited from the SafeChrom project. Cr concentrations were measured in RBC (biomarker of long-term exposure) and urine (biomarker of short-term exposure) samples. Long ncRNA (lncRNA) and microRNA (miRNA) were extracted from plasma followed by deoxyribonuclease treatment, complementary DNA synthesis, and quantitative real-time polymerase chain reaction using target-specific assays for three lncRNAs (H19, MALAT1, NORAD), and four miRNAs (miR-142-3p, miR-15b-5p, miR-3940-5p, miR-451a).Results: Expression levels of lncRNAs MALAT1 and NORAD, and all four miRNAs, were significantly lower in Cr (VI) exposed workers compared with controls, and correlated significantly with RBC-Cr concentrations (rS = -0.16 to -0.38). H19 was non-significantly increased in exposed workers but significantly correlated with miR142-3p (rS = -0.33) and miR-15b-5p (rS = -0.30), and NORAD was significantly positively correlated with all four miRNAs (rS = 0.17 to 0.46). In multivariate regression models adjusting for confounders, expressions of lncRNAs MALAT1 and NORAD and all miRNAs were still significantly lower in the exposed group compared with controls, and the expression decreased with increasing RBC-Cr concentrations. Conclusions: Cr(VI) exposure was inversely and in a dose-response manner associated with the expression of circulating non-coding RNA, which suggests ncRNAs as potential biomarkers for Cr(VI)-induced toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Hexavalent chromium
- miRNA
- lncRNA
- RBC chromium
- Biomarkers
- Lung cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Jiang, Zheshun
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Person, Romane
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Lundh, Thomas
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Pineda, Daniela
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Engfeldt, Malin
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Krais, Annette M
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visa fler...
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Hagberg, Jessika ...
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Ricklund, Niklas ...
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Vogel, Ulla
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Saber, Anne T.
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Tondel, Martin
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Albin, Maria
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Broberg, Karin
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SafeChrom Projec ...
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Uppsala universitet
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Örebro universitet
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Lunds universitet