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Clinical presentati...
Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
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Murdoch, David R (author)
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Corey, G Ralph (author)
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Hoen, Bruno (author)
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Miró, José M (author)
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Fowler, Vance G (author)
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Bayer, Arnold S (author)
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Karchmer, Adolf W (author)
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- Olaison, Lars, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Pappas, Paul A (author)
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Moreillon, Philippe (author)
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Chambers, Stephen T (author)
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Chu, Vivian H (author)
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Falcó, Vicenç (author)
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Holland, David J (author)
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Jones, Philip (author)
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Klein, John L (author)
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Raymond, Nigel J (author)
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Read, Kerry M (author)
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Tripodi, Marie Francoise (author)
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Utili, Riccardo (author)
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Wang, Andrew (author)
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Woods, Christopher W (author)
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Cabell, Christopher H (author)
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(creator_code:org_t)
- American Medical Association (AMA), 2009
- 2009
- English.
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In: Archives of internal medicine. - : American Medical Association (AMA). - 1538-3679 .- 0003-9926. ; 169:5, s. 463-73
- Related links:
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https://jamanetwork....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. RESULTS: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hallmarks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. CONCLUSIONS: In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Adult
- Aged
- Endocarditis
- microbiology
- mortality
- therapy
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Staphylococcal Infections
- microbiology
- Staphylococcus aureus
- isolation & purification
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Murdoch, David R
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Corey, G Ralph
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Hoen, Bruno
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Miró, José M
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Fowler, Vance G
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Bayer, Arnold S
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show more...
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Karchmer, Adolf ...
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Olaison, Lars, 1 ...
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Pappas, Paul A
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Moreillon, Phili ...
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Chambers, Stephe ...
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Chu, Vivian H
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Falcó, Vicenç
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Holland, David J
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Jones, Philip
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Klein, John L
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Raymond, Nigel J
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Read, Kerry M
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Tripodi, Marie F ...
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Utili, Riccardo
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Wang, Andrew
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Woods, Christoph ...
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Cabell, Christop ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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University of Gothenburg