Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients.

• Gastric adenocarcinoma is closely associated with Helicobacter pylori infection. It is also much more frequent in patients with common variable immunodeficiency or selective IgA-deficiency than in the general population. To investigate a possible link between local antibody production and gastric tumors, we studied gastric B cell infiltration and local IgA production in patients with H. pylori induced gastric adenocarcinomas. These studies showed that total and H. pylori-specific IgA antibody levels were substantially lower in gastric tissue from the cancer patients compared to those from asymptomatic H. pylori carriers. However, serum IgA levels were similar in the cancer patients and asymptomatic carriers. As could be expected, H. pylori infected asymptomatic carriers had considerably increased IgA antibody levels compared to uninfected subjects. We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

Adenocarcinoma

immunology

microbiology

Aged

Aged

80 and over

Antibodies

Bacterial

immunology

metabolism

B-Lymphocytes

immunology

metabolism

microbiology

Chemokines

immunology

metabolism

Female

Gastric Mucosa

immunology

Helicobacter Infections

complications

immunology

microbiology

Helicobacter pylori

immunology

Humans

Immunoglobulin A

analysis

immunology

Male

Middle Aged

Plasma Cells

immunology

metabolism

microbiology

Stomach Neoplasms

immunology

microbiology

Urease

immunology

metabolism

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)