Autoantibodies in atrial fibrillation: actor, biomaker or bystander?

• Atrial fibrillation (AF) is one of the most common arrhythmias in patients with congestive heart failure, although the underlying mechanism has still to be determined. There is increasing evidence to suggest that autoimmunity may play an important role in the pathogenesis of AF. To date, at least three types of autoantibody have been found in AF: the anti-myosin heavy chain autoantibody, the anti-M2 muscarinic receptor autoantibody and the anti-heat shock protein autoantibody. The question is: are these autoantibodies actors, biomakers or merely bystanders? How much knowledge do we have?

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Atrial Fibrillation

immunology

metabolism

Autoantibodies

immunology

Autoimmunity

Biological Markers

metabolism

Cardiac Myosins

immunology

Heat-Shock Proteins

immunology

Humans

Myosin Heavy Chains

immunology

Receptor

Muscarinic M2

immunology

Publikations- och innehållstyp

ref (ämneskategori)

for (ämneskategori)