Thrombocytopenia in early alcohol withdrawal is associated with development of delirium tremens or seizures.

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Berggren, Ulf,1948Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (author)

Thrombocytopenia in early alcohol withdrawal is associated with development of delirium tremens or seizures.

Article/chapterEnglish2009

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2009-03-16
Oxford University Press (OUP),2009

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LIBRIS-ID:oai:gup.ub.gu.se/108606
https://gup.ub.gu.se/publication/108606URI
https://doi.org/10.1093/alcalc/agp012DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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AIMS: In several studies, possible risk factors/predictors for severe alcohol withdrawal syndrome (AWS), i.e. delirium tremens (DT) and/or seizures, have been investigated. We have recently observed that low blood platelet count could be such a risk factor/predictor. We therefore investigated whether such an association could be found using a large number of alcohol-dependent individuals (n = 334). METHODS: This study is a retrospectively conducted cohort study based on data from female and male patients (>20 years of age), consecutively admitted to an alcohol treatment unit. The individuals had to fulfil the discharge diagnoses alcohol dependence and alcohol withdrawal syndrome according to DSM-IV. RESULTS: During the treatment period, 3% of the patients developed DT, 2% seizures and none had co-occurrence of both conditions. Among those with DT, a higher proportion had thrombocytopenia. Those with seizures had lower blood platelet count and a higher proportion of them had thrombocytopenia. The sensitivity and specificity of thrombocytopenia for the development of DT during the treatment period was 70% and 69%, respectively. The positive predictive value (PPV) was 6% and the negative predictive value (NPV) was 99%. For the development of seizures, the figure for sensitivity was 75% and for specificity 69%. The figures for PPV and NPV were similar as those for the development of DT. CONCLUSIONS: Thrombocytopenia is more frequent in patients who develop severe AWS (DT or seizures). The findings, including the high NPV of thrombocytopenia, must be interpreted with caution due to the small number of patients who developed AWS. Further studies replicating the present finding are therefore needed before the clinical usefulness can be considered.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
SAMHÄLLSVETENSKAP Psykologi hsv//swe
SOCIAL SCIENCES Psychology hsv//eng
Adult
Aged
Alcohol Withdrawal Delirium
epidemiology
etiology
Blood Cell Count
Central Nervous System Depressants
adverse effects
Ethanol
adverse effects
Female
Hemoglobins
metabolism
Humans
Leukocyte Count
Male
Middle Aged
Retrospective Studies
Risk Factors
Seizures
epidemiology
etiology
Sex Factors
Substance Withdrawal Syndrome
epidemiology
etiology
Thrombocytopenia
epidemiology
etiology
Young Adult

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Fahlke, Claudia,1964Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xfahcl (author)
Berglund, Kristina,1969Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xberkr (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Balldin, Jan,1935Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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In:Alcohol and alcoholism (Oxford, Oxfordshire): Oxford University Press (OUP)44:4, s. 382-61464-35020735-0414

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