CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa.

Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adjuvants
Immunologic
genetics
therapeutic use
Animals
B-Lymphocytes
drug effects
immunology
metabolism
pathology
Chlamydia Infections
complications
immunology
therapy
Chlamydia muridarum
immunology
pathogenicity
Chlamydia trachomatis
immunology
pathogenicity
Cholera Toxin
genetics
immunology
therapeutic use
Female
Genitalia
immunology
microbiology
pathology
Humans
Immunization
Immunoglobulins
blood
Infertility
etiology
prevention & control
Mice
Mice
Inbred BALB C
Mucous Membrane
immunology
microbiology
pathology
Porins
immunology
Recombinant Fusion Proteins
genetics
immunology
therapeutic use

Carey, Alison J (författare)
Lycke, Nils Y,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xlycni (författare)
Timms, Peter (författare)
Beagley, Kenneth W (författare)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)

Ingår i:Journal of reproductive immunology: Elsevier BV81:1, s. 34-81872-76030165-0378

Av författaren/redakt...: Cunningham, Kell ...; Carey, Alison J; Lycke, Nils Y, 1 ...; Timms, Peter; Beagley, Kenneth ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

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