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  • Ahmad, ShafqatLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups (author)

A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2015-08-17
  • Springer Science and Business Media LLC,2016

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:0ec1cb35-260a-427a-a06f-36a9b6fb263c
  • https://lup.lub.lu.se/record/7840841URI
  • https://doi.org/10.1038/ijo.2015.152DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-114898URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489438URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BackgroundObesity is a complex disease caused by the interplay of genetic and lifestyle factors, but identification of gene-lifestyle interactions in obesity has remained challenging. Few large-scale studies have reported use of genome-wide approaches to investigate gene-lifestyle interactions in obesity.MethodsIn the PROMIS study, a cross-sectional study based in Pakistan, we calculated BMI variance estimates (square of the residual of inverse-normal transformed BMI z-score) in 14 131 participants and conducted genome-wide heterogeneity of variance analyses (GWHVA) for this outcome. All analyses were adjusted for age, age(2), sex and genetic ancestry.ResultsThe GWHVA analyses yielded a genome-wide significance (P-value=3.1 × 10(-8)) association of the rs140133294 variant at FLJ33534 with BMI variance. In explicit tests of gene × lifestyle interaction, smoking was found to significantly modify the effect of rs140133294 on BMI (Pinteraction=0.0005), whereby the minor allele (T) was associated with lower BMI in current smokers, while positively associated with BMI in never-smokers. No interactions with physical activity were observed. Analyses of ENCODE data at the FLJ33534 locus revealed features indicative of open chromatin and high confidence DNA-binding motifs for several transcription factors, providing suggestive biological support for a mechanism of interaction.ConclusionIn summary, we have identified a novel interaction between smoking and variation at the FLJ33534 locus in relation to BMI in people from Pakistan.International Journal of Obesity accepted article preview online, 17 August 2015. doi:10.1038/ijo.2015.152.

Subject headings and genre

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  • Zhao, W (author)
  • Renström, FridaLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm (author)
  • Rasheed, A (author)
  • Zaidi, M (author)
  • Samuel, M (author)
  • Shah, N (author)
  • Mallick, N H (author)
  • Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin,Institutionen för odontologi(Swepub:umu)dmsh0003 (author)
  • Zaman, K S (author)
  • Ishaq, M (author)
  • Rasheed, S Z (author)
  • Memon, F-U-R (author)
  • Hanif, B (author)
  • Lakhani, M S (author)
  • Ahmed, F (author)
  • Kazmi, S U (author)
  • Deloukas, P (author)
  • Frossard, P (author)
  • Franks, PaulLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (author)
  • Saleheen, D (author)
  • Genetisk och molekylär epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:International Journal of Obesity: Springer Science and Business Media LLC40:1, s. 186-1901476-54970307-0565

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