Search: WFRF:(Mårild Staffan 1945) >
Ceftibuten versus t...
Ceftibuten versus trimethoprim-sulfamethoxazole for oral treatment of febrile urinary tract infection in children
-
- Mårild, Staffan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Jodal, Ulf, 1938 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Sandberg, Torsten, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
(creator_code:org_t)
- 2009
- 2009
- English.
-
In: Pediatric Nephrology. - 0931-041X. ; 24:3, s. 521-6
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- A randomized, open, coordinated multi-center trial compared the bacteriological and clinical efficacy and safety of orally administered ceftibuten and trimethoprim-sulfamethoxazole (TMP-SMX) in children with febrile urinary tract infection (UTI). Children aged 1 month to 12 years presenting with presumptive first-time febrile UTI were eligible for enrollment. A 2:1 assignment to treatment with ceftibuten 9 mg/kg once daily (n = 368) or TMP-SMX (3 mg + 15 mg)/kg twice daily (n = 179) for 10 days was performed. Escherichia coli was recovered in 96% of the cases. Among the E. coli isolates, 14% were resistant to TMP-SMX but none to ceftibuten. In the modified intention-to-treat population, the bacteriological elimination rates at follow-up did not differ significantly between patients treated with ceftibuten and those treated with TMP-SMX [91 vs. 95%, with a 95% confidence interval (CI) for difference of -9.7 to 1.0]. However, the clinical cure rate was significantly higher among those treated with ceftibuten (93 vs. 83%, with a 95% CI for difference of 2.4 to 17.0). Adverse events were similar for both regimens and consisted mainly of gastrointestinal disturbances. In conclusion, ceftibuten is a safe and effective drug for the empirical treatment of febrile UTI in young children.
Keyword
- Anti-Infective Agents/*therapeutic use
- Cephalosporins/adverse effects/*therapeutic use
- Child
- Child
- Preschool
- Female
- Fever/drug therapy
- Humans
- Infant
- Male
- Prospective Studies
- Trimethoprim-Sulfamethoxazole Combination/adverse effects/*therapeutic use
- Urinary Tract Infections/*drug therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database