SPECIES EXTRAPOLATION FOR THE 21ST CENTURY

• Ecological risk assessment is facing the need for increasing sophistication that will require a scientific rationale for making appropriate informed extrapolations. This will inevitably require sound biological linkages amongst species in their responses to chemical stressors. It is important to acknowledge the tools and knowledge are currently here for extrapolations based on omics data to begin. However, limitations in our understanding of the complexity molecular target expression form and function with their response to the multitude of mechanisms of actions mean that our ambitions in this field require considerable further development. A conceptual approach is presented and illustrated with a case study with an aromatase inhibiting mode of action. This paper aims to highlight the potential short and medium term development goals in order to meet our long term aspiration for in silico extrapolation across species response to toxicants.

Ämnesord

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

species extrapolation

aromatase

CYP19

vitellogenin

fish

Publikations- och innehållstyp

vet (ämneskategori)

kon (ämneskategori)