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Longitudinal one-ye...
Longitudinal one-year study of levels and stoichiometry of neurofilament heavy and light chain concentrations in CSF in patients with multiple system atrophy.
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- Petzold, Axel (författare)
- University College London
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- Thompson, Edward J (författare)
- University College London
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- Keir, Geoffrey (författare)
- University College London
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- Quinn, Niall (författare)
- University College London
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- Holmberg, Björn (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg
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- Dizdar Segrell, Nil (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken
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- Wenning, Gregor K (författare)
- University of Innsbruck Hospital
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- Rascol, Olivier (författare)
- Hop Purpan
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- Tolosa, Eduardo (författare)
- University of Barcelona
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- Rosengren, Lars, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Journal of the neurological sciences. - : Elsevier BV. - 1878-5883 .- 0022-510X. ; 279:1-2, s. 76-9
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Two cerebrospinal fluid (CSF) biomarkers specific for neurodegeneration have recently emerged - the neurofilament light (NfL, 68 kDa) and heavy (NfH, 190-210 kDa) chains. This study investigated whether the CSF NfH and NfL levels or their stoichiometric relationship changed over time in a neuroprotective treatment trial. METHODS: Serial CSF samples (n=95) from 42 patients with multiple system atrophy (MSA), half randomized to treatment with recombinant human growth hormone (r-hGH) and the other half to placebo, were collected at baseline, 6 and 12 months. The concentration of CSF NfL and NfH was determined using standard ELISAs. RESULTS: There was no consistent change in the levels of either protein over the 12 month period, or between treatment with active r-hGH versus placebo. The molar stoichiometry of CSF NfL:NfH was 4:1 (R=0.37, p=0.0002) and increased following treatment with r-hGH (p=0.03). CONCLUSION: These results indicate that CSF levels of both NfL and NfH on their own are not useful markers of disease progression in MSA, at least over a 12-month period. Future work is needed to elucidate whether the CSF stoichiometry and dynamics of Nf subunits in individual patients are a feature of the underlying pathology and of diagnostic or prognostic value.
Nyckelord
- Adult
- Aged
- Aged
- 80 and over
- Biological Markers
- cerebrospinal fluid
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- Human Growth Hormone
- biosynthesis
- therapeutic use
- Humans
- Linear Models
- Longitudinal Studies
- Male
- Middle Aged
- Multiple System Atrophy
- cerebrospinal fluid
- drug therapy
- Neurofilament Proteins
- cerebrospinal fluid
- Neuroprotective Agents
- therapeutic use
- Recombinant Proteins
- therapeutic use
- Neurofilament
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Petzold, Axel
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Thompson, Edward ...
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Keir, Geoffrey
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Quinn, Niall
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Holmberg, Björn
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Dizdar Segrell, ...
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visa fler...
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Wenning, Gregor ...
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Rascol, Olivier
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Tolosa, Eduardo
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Rosengren, Lars, ...
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- Artiklar i publikationen
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Journal of the n ...
- Av lärosätet
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Göteborgs universitet
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Linköpings universitet