Mitochondrial membrane permeabilization in neuronal injury.

Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells will succumb to or survive the injury, and represents a 'point of no return' in mitochondrial cell death. It is therefore an attractive target for the development of new neuroprotective interventions.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
Animals
Apoptosis
physiology
Electron Transport
physiology
Mitochondria
metabolism
ultrastructure
Mitochondrial Membranes
metabolism
Mitogen-Activated Protein Kinases
genetics
metabolism
Molecular Chaperones
genetics
metabolism
Necrosis
Neurons
cytology
metabolism
pathology
Oxidation-Reduction
Peptide Hydrolases
genetics
metabolism
Permeability
Proto-Oncogene Proteins c-bcl-2
genetics
metabolism

Blomgren, Klas,1963Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institutionen för kliniska vetenskaper,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Institute of Clinical Sciences(Swepub:gu)xblokl (author)
Kroemer, Guido (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

In:Nature reviews. Neuroscience: Springer Science and Business Media LLC10:7, s. 481-941471-00481471-003X

By the author/editor: Galluzzi, Lorenz ...; Blomgren, Klas, ...; Kroemer, Guido

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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