Mitochondrial membrane permeabilization in neuronal injury.

• Acute neurological conditions such as cerebrovascular diseases and trauma are associated with irreversible loss of neurons and glial cells. Severe or prolonged injury results in uncontrollable cell death within the core of lesions. Conversely, cells that are less severely damaged succumb in a relatively slow fashion, frequently via the intrinsic pathway of cell death, through the deterioration of mitochondrial functions. The permeabilization of mitochondrial membranes determines whether cells will succumb to or survive the injury, and represents a 'point of no return' in mitochondrial cell death. It is therefore an attractive target for the development of new neuroprotective interventions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

Animals

Apoptosis

physiology

Electron Transport

physiology

Mitochondria

metabolism

ultrastructure

Mitochondrial Membranes

metabolism

Mitogen-Activated Protein Kinases

genetics

metabolism

Molecular Chaperones

genetics

metabolism

Necrosis

Neurons

cytology

metabolism

pathology

Oxidation-Reduction

Peptide Hydrolases

genetics

metabolism

Permeability

Proto-Oncogene Proteins c-bcl-2

genetics

metabolism

Publication and Content Type

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