The ratio of n-6 to n-3 fatty acids in maternal diet influences the induction of neonatal immunological tolerance to ovalbumin

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Korotkova, Marina,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research (author)

The ratio of n-6 to n-3 fatty acids in maternal diet influences the induction of neonatal immunological tolerance to ovalbumin

Article/chapterEnglish2004

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2004-06-15
Oxford University Press (OUP),2004

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LIBRIS-ID:oai:gup.ub.gu.se/117070
https://gup.ub.gu.se/publication/117070URI
https://doi.org/10.1111/j.1365-2249.2004.02527.xDOI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Prevalence of allergy is increasing in many countries and might be related to changed environmental factors, such as dietary fatty acids (FA). The present study investigates whether dietary ratio of n-6 to n-3 FA influences the induction of immunological tolerance to ovalbumin (OA) in neonatal rats. During late gestation and throughout lactation Sprague-Dawley rats were fed a diet containing 7% linseed oil (n-3 diet), sunflower oil (n-6 diet) or soybean oil (n-6/n-3 diet). At 10-16 days of age the rat offspring were subsequently exposed, or not, to OA via the milk. The offspring were weaned onto the same diets as the mothers and immunized with OA and the bystander antigen human serum albumin (HSA). In the offspring on the n-3 diet exposure to OA via the milk resulted in lower delayed type hypersensitivity reaction (DTH) and antibody responses against both OA and HSA, compared to those in the offspring not exposed to OA, indicating the induction of oral tolerance. In the offspring on the n-6 diet, the exposure to OA led to depressed specific immune responses against only OA, not HSA. In the offspring on the n-6/n-3 diet oral exposure to OA did not influence immune responses against OA, or HSA. The results indicate that the dietary ratio of n-6/n-3 FA is important for the induction of neonatal oral tolerance. Thus nonoptimal feeding may have effects on the development of immunological tolerance to dietary antigen ingested by the mother. The ratio of n-6/n-3 FA in the diet may be considered in the context of increased prevalence of allergy.

Subject headings and genre

Animals
Animals
Newborn
Diet
Dietary Fats
Unsaturated
administration & dosage
Fatty Acids
Omega-3
administration & dosage
Fatty Acids
Omega-6
administration & dosage
Female
Humans
Hypersensitivity
Delayed
immunology
Immune Tolerance
immunology
Lactation
immunology
Lymph Nodes
anatomy & histology
Mammary Glands
Human
immunology
Organ Size
Ovalbumin
immunology
Phospholipids
blood
Pregnancy
Rats
Rats
Sprague-Dawley

Added entries (persons, corporate bodies, meetings, titles ...)

Telemo, Esbjörn,1953Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology(Swepub:gu)xteles (author)
Yamashiro, Y (author)
Hanson, Lars Åke,1934Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology(Swepub:gu)xhlart (author)
Strandvik, Birgitta,1938Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics(Swepub:gu)xstrab (author)
Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)

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In:Clinical and experimental immunology: Oxford University Press (OUP)137:2, s. 237-440009-91041365-2249

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