SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Larsen Niels B.)
 

Search: WFRF:(Larsen Niels B.) > The Imprinted Gene ...

The Imprinted Gene Neuronatin Is Regulated by Metabolic Status and Associated With Obesity.

Vrang, Niels (author)
Meyre, David (author)
Froguel, Phillippe (author)
show more...
Jelsing, Jacob (author)
Tang-Christensen, Mads (author)
Vatin, Vincent (author)
Mikkelsen, Jens D (author)
Thirstrup, Kenneth (author)
Larsen, Leif K (author)
Cullberg, Karina B (author)
Fahrenkrug, Jan (author)
Jacobson, Peter, 1962 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Institute of Medicine, Department of Internal Medicine
Sjöström, Lars (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Institute of Medicine, Department of Internal Medicine
Carlsson, Lena M S, 1957 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Institute of Medicine, Department of Internal Medicine
Liu, Yongjun (author)
Liu, Xiaogang (author)
Deng, Hong-Wen (author)
Larsen, Philip J (author)
show less...
 (creator_code:org_t)
2012-09-06
2010
English.
In: Obesity. - : Wiley. - 1930-7381. ; 18:7, s. 1289-1296
Related links:
https://onlinelibrar...
show more...
https://gup.ub.gu.se...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

  • Obesity (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view