Search: WFRF:(Riise Gerdt C. 1956) >
Glycosphingolipid r...
Glycosphingolipid receptors for Pseudomonas aeruginosa.
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Baker, N (author)
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- Hansson, Gunnar C., 1951 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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Leffler, Hakon (author)
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Riise, Gerdt C., 1956 (author)
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Svanborg-Edén, Catharina (author)
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(creator_code:org_t)
- 1990
- 1990
- English.
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In: Infection and immunity. - 0019-9567. ; 58:7, s. 2361-6
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- The binding of Pseudomonas aeruginosa to glycosphingolipids and to buccal and bronchial epithelial cells was analyzed. Three independently expressed specificities were found by bacterial binding to glycosphingolipids separated by thin-layer chromatography. All strains bound gangliotria- and gangliotetrasylceramide. All but one of the strains bound sialic acid-containing glycosphingolipids and lactosylceramide. The latter two specificities could be separated in that the lactosylceramide binding was retained and the sialic acid binding was suppressed when bovine serum albumin was used as a blocking agent in the thin-layer chromatography assay. The attachment to buccal epithelial cells, like the binding to sialylated compounds and lactosylceramide, was abolished by Formalin treatment of the bacteria, suggesting the importance of these specificities for cell adherence. In contrast, the binding to gangliotria- and gangliotetraosylceramide was retained by nonattaching Formalin-treated bacteria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Antigens
- CD
- Bacterial Adhesion
- physiology
- Carbohydrate Sequence
- Epithelium
- microbiology
- Glycosphingolipids
- metabolism
- Humans
- Lactosylceramides
- Molecular Sequence Data
- Mouth
- microbiology
- N-Acetylneuraminic Acid
- Pseudomonas aeruginosa
- metabolism
- Sialic Acids
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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