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Exenatide affected ...
Exenatide affected circulating cardiovascular risk biomarkers independently of changes in body composition
- Article/chapterEnglish2010
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LIBRIS-ID:oai:gup.ub.gu.se/121218
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https://gup.ub.gu.se/publication/121218URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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OBJECTIVE To study the effect of exenatide on body composition and circulating cardiovascular risk biomarkers. RESEARCH DESIGN AND METHODS Metformin-treated patients with type 2 diabetes (N = 69) were randomized to exenatide or insulin glargine and treated for 1 year. Body composition was evaluated by dual-energy X-ray absorptiometry. Additionally, body weight, waist circumference, and cardiovascular biomarkers were measured. RESULTS Treatment with exenatide for 1 year significantly reduced body weight, waist circumference, and total body and trunkal fat mass by 6, 5, 11, and 13%, respectively. In addition, exenatide increased total adiponectin by 12% and reduced high-sensitivity C-reactive protein by 61%. Insulin glargine significantly reduced endothelin-1 by 7%. These changes were statistically independent of the change in total body fat mass and body weight. CONCLUSIONS Exenatide treatment for 1 year reduced body fat mass and improved the profile of circulating biomarkers of cardiovascular risk. No significant changes were seen with insulin glargine except a trend for reduced endothelin-1 levels.
Added entries (persons, corporate bodies, meetings, titles ...)
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Diamant, M.
(author)
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Eliasson, Björn,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xelibj
(author)
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Corner, A.
(author)
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Shaginian, R. M.
(author)
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Heine, R. J.
(author)
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Taskinen, Marja-Riitta
(author)
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Yki-Järvinen, Hannele
(author)
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Smith, Ulf,1943Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmiul
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Related titles
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In:Diabetes Care33:8, s. 1734-17370149-5992
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Bunck, M. C.
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Diamant, M.
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Eliasson, Björn, ...
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Corner, A.
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Shaginian, R. M.
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Heine, R. J.
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Taskinen, Marja- ...
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Yki-Järvinen, Ha ...
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Smith, Ulf, 1943
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Diabetes Care
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University of Gothenburg