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Mapping of a functi...
Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.
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- Magnusson, Yvonne, 1957 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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Marullo, S (author)
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- Hoyer, S (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Waagstein, Finn, 1938 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Andersson, Bert, 1952 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Vahlne, A (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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Guillet, J G (author)
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Strosberg, A D (author)
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- Hjalmarson, Agneta, 1943 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Hoebeke, Johan (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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(creator_code:org_t)
- 1990
- 1990
- English.
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In: The Journal of clinical investigation. - 0021-9738. ; 86:5, s. 1658-63
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Abstract
Subject headings
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- The presence and properties of serum autoantibodies against beta-adrenergic receptors in patients with idiopathic dilated cardiomyopathy were studied using synthetic peptides derived from the predicted sequences of the human beta-adrenergic receptors. Peptides corresponding to the sequences of the second extracellular loop of the human beta 1- and beta 2-adrenergic receptors were used as antigens in an enzyme immunoassay to screen sera from patients with dilated cardiomyopathy (n = 42), ischemic heart disease (n = 17), or healthy blood donors (n = 34). The sera of thirteen dilated cardiomyopathy patients, none of the ischemic heart disease patients, and four of the healthy controls monospecifically recognized the beta 1-peptide. Only affinity-purified antibodies of these patients had a inhibitory effect on radioligand binding to the beta 1 receptor of C6 rat glioma cells. They recognized the receptor protein by immunoblot and bound in situ to human myocardial tissue. We conclude that a subgroup of patients with idiopathic dilated cardiomyopathy have in their sera autoantibodies specifically directed against the second extracellular loop of the beta 1-adrenergic receptor. These antibodies could serve as a marker of an autoimmune response with physiological and/or pathological implications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Adult
- Aged
- Amino Acid Sequence
- Antibody Affinity
- Autoantibodies
- blood
- immunology
- Autoimmune Diseases
- immunology
- Cardiomyopathy
- Dilated
- immunology
- Epitopes
- immunology
- Female
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Molecular Sequence Data
- Receptors
- Adrenergic
- beta
- chemistry
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Magnusson, Yvonn ...
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Marullo, S
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Hoyer, S
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Waagstein, Finn, ...
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Andersson, Bert, ...
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Vahlne, A
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show more...
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Guillet, J G
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Strosberg, A D
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Hjalmarson, Agne ...
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Hoebeke, Johan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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The Journal of c ...
- By the university
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University of Gothenburg