Pertussis vaccine: a critique.

• A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

Adhesins

Bacterial

immunology

Adult

Animals

Bacterial Outer Membrane Proteins

immunology

Bordetella pertussis

immunology

Child

Diphtheria-Tetanus-Pertussis Vaccine

Humans

Immunity

Herd

Immunoglobulin G

blood

Mice

Pertussis Toxin

immunology

Pertussis Vaccine

administration & dosage

immunology

Toxoids

genetics

immunology

therapeutic use

Vaccines

Inactivated

administration & dosage

immunology

Virulence Factors

Bordetella

immunology

Whooping Cough

epidemiology

immunology

prevention & control

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)