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Up-regulation of ce...
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Möllerström, ElinGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
(author)
Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray.
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-06-16
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Springer Science and Business Media LLC,2010
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/122957
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https://gup.ub.gu.se/publication/122957URI
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https://doi.org/10.1186/1471-2407-10-296DOI
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https://lup.lub.lu.se/record/1657649URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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ABSTRACT: BACKGROUND: Previous studies have shown that the ADIPOR1, ADORA1, BTG2 and CD46 genes differ significantly between long-term survivors of breast cancer and deceased patients, both in levels of gene expression and DNA copy numbers. The aim of this study was to characterize the expression of the corresponding proteins in breast carcinoma and to determine their correlation with clinical outcome. METHODS: Protein expression was evaluated using immunohistochemistry in an independent breast cancer cohort of 144 samples represented on tissue microarrays. Fisher's exact test was used to analyze the differences in protein expression between dead and alive patients. We used Cox-regression multivariate analysis to assess whether the new markers predict the survival status of the patients better than the currently used markers. RESULTS: BTG2 expression was demonstrated in a significantly lower proportion of samples from dead patients compared to alive patients, both in overall expression (P=0.026) and cell membrane specific expression (P=0.013), whereas neither ADIPOR1, ADORA1 nor CD46 showed differential expression in the two survival groups. Furthermore, a multivariate analysis showed that a model containing BTG2 expression in combination with HER2 and Ki67 expression along with patient age performed better than a model containing the currently used prognostic markers (tumour size, nodal status, HER2 expression, hormone receptor status, histological grade, and patient age). Interestingly, BTG2 has previously been described as a tumour suppressor gene involved in cell cycle arrest and p53 signalling. CONCLUSIONS: We conclude that high-level BTG2 protein expression correlates with prolonged survival in patients with breast carcinoma.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
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Age Factors
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Aged
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Antigens
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CD46
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analysis
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Breast Neoplasms
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chemistry
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mortality
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pathology
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therapy
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Carcinoma
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chemistry
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mortality
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pathology
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therapy
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Female
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Humans
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Immediate-Early Proteins
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analysis
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Immunohistochemistry
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Kaplan-Meier Estimate
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Ki-67 Antigen
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analysis
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Middle Aged
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Predictive Value of Tests
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Proportional Hazards Models
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Receptor
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Adenosine A1
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analysis
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Receptor
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erbB-2
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analysis
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Receptors
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Adiponectin
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analysis
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Risk Assessment
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Risk Factors
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Sweden
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epidemiology
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Time Factors
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Tissue Array Analysis
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Treatment Outcome
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Tumor Markers
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Biological
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analysis
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Tumor Suppressor Proteins
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analysis
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Up-Regulation
Added entries (persons, corporate bodies, meetings, titles ...)
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Kovács, Anikó,1961Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology(Swepub:gu)xkovan
(author)
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Lövgren, KristinaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-klo
(author)
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Nemes, Szilard,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xnemsz
(author)
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Delle, Ulla,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xdelul
(author)
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Danielsson, Anna,1973Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xdanne
(author)
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Parris, Toshima Z,1978Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xparto
(author)
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Brennan, Donal J
(author)
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Jirström, KarinLund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji
(author)
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Karlsson, Per,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xkperd
(author)
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Helou, Khalil,1966Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xhelkh
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för onkologi
(creator_code:org_t)
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In:BMC cancer: Springer Science and Business Media LLC10:11471-2407
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