Melanocortin 1 receptor agonists reduce proteinuria.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: L773:1046 6673 > (2010-2014) > Melanocortin 1 rece...

Details
MARC

Lindskog, Annika,1982Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

Melanocortin 1 receptor agonists reduce proteinuria.

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/127939
https://gup.ub.gu.se/publication/127939URI
https://doi.org/10.1681/ASN.2009101025DOI
https://lup.lub.lu.se/record/1675422URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown. Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial cells, and tubular epithelial cells. Podocytes expressed most MC1R protein, which colocalized with synaptopodin but not with an endothelial-specific lectin. We treated rats with passive Heymann nephritis (PHN) with MS05, a specific MC1R agonist, which significantly reduced proteinuria compared with untreated PHN rats (P < 0.01). Furthermore, treatment with MC1R agonists improved podocyte morphology and reduced oxidative stress. In summary, podocytes express MC1R, and MC1R agonism reduces proteinuria, improves glomerular morphology, and reduces oxidative stress in nephrotic rats with PHN. These data may explain the proteinuria-reducing effects of ACTH observed in patients with membranous nephropathy, and MC1R agonists may provide a new therapeutic option for these patients.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
Adrenocorticotropic Hormone
therapeutic use
Adult
Aged
Animals
Disease Models
Animal
Endothelial Cells
metabolism
Female
Glomerulonephritis
Membranous
complications
Hormones
therapeutic use
Humans
Male
Mesangial Cells
metabolism
Middle Aged
Podocytes
metabolism
Proteinuria
etiology
prevention & control
Rats
Receptor
Melanocortin
Type 1
agonists
biosynthesis
Urothelium
cytology
metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

Ebefors, Kerstin,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xolker (author)
Johansson, Martin E,1968Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)med-mim (author)
Stefánsson, Bergur V.Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xstefb (author)
Björnson Granqvist, Anna,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbjora (author)
arnadottir, margret (author)
Berg, Anna-LenaLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-alb (author)
Nyström, Jenny,1972Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xnysje (author)
Haraldsson, Börje,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xharbo (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

In:Journal of the American Society of Nephrology : JASN21:8, s. 1290-81533-34501046-6673

Internet link

Find in a library

Journal of the American Society of Nephrology : JASN (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Lindskog, Annika ...; Ebefors, Kerstin ...; Johansson, Marti ...; Stefánsson, Berg ...; Björnson Granqvi ...; arnadottir, marg ...; show more...; Berg, Anna-Lena; Nyström, Jenny, ...; Haraldsson, Börj ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

Articles in the publication: Journal of the A ...

By the university: University of Gothenburg; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se