Sexual function and surgical outcome in women with congenital adrenal hyperplasia due to CYP21A2 deficiency: clinical perspective and the patients' perception.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Thoren Marja) > Sexual function and...

Details
MARC

Nordenström, AnnaKarolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology (author)

Sexual function and surgical outcome in women with congenital adrenal hyperplasia due to CYP21A2 deficiency: clinical perspective and the patients' perception.

Article/chapterEnglish2010

Publisher, publication year, extent ...

The Endocrine Society,2010

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/128962
https://gup.ub.gu.se/publication/128962URI
https://doi.org/10.1210/jc.2009-2639DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121091938URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

CONTEXT: Females with congenital adrenal hyperplasia (CAH) due to a CYP21A2 deficiency are exposed to androgens during fetal development, resulting in virilization of the external genitalia. Little is known about how these women feel that the disease has affected their lives regarding surgery and psychosexual adaptation. OBJECTIVE: Our objective was to investigate the correlation between the surgical results, the self-perceived severity of the disease, and satisfaction with sexual life and relate the results to the CYP21A2 genotype. DESIGN AND PARTICIPANTS: Sixty-two Swedish women with CAH and age-matched controls completed a 120-item questionnaire, and a composite score for sexual function was constructed. The surgical outcome, including genital appearance and clitoral sensitivity, was evaluated by clinical examination. The patients were divided into four CYP21A2 genotype groups. RESULTS: The sexual function score, but not for genital appearance, was higher in the patients satisfied with their sexual life. This was also true of the patients who were satisfied with the surgical result. There were discrepancies between the patients' perception of the impact of the condition on their sexual life and what health professionals would assume from clinical examination. The patients in the null genotype group scored lower on sexual function and satisfaction with their sexual life and had more surgical complications, also compared with the slightly less severe I2-splice genotype group. CONCLUSION: Our data show that the null genotype group was considerably more affected by the condition than the other groups and should be regarded as a subgroup, both psychologically and from a surgical perspective. Genotyping adds clinically valuable information.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Adolescent
Adrenal Hyperplasia
Congenital
genetics
psychology
surgery
Adult
Body Image
Clitoris
surgery
Female
Genotype
Health Surveys
Humans
Middle Aged
Mutation
Patient Satisfaction
Quality of Life
psychology
Questionnaires
Severity of Illness Index
Sexual Behavior
psychology
Statistics
Nonparametric
Steroid 21-Hydroxylase
genetics
Sweden
Treatment Outcome
Virilism
genetics
psychology
surgery

Added entries (persons, corporate bodies, meetings, titles ...)

Frisén, LouiseKarolinska Institutet (author)
Falhammar, HenrikKarolinska Institutet (author)
Filipsson, Helena (author)
Holmdahl, Gundela,1956Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xhogun (author)
Janson, Per-Olof,1940Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjperm (author)
Thorén, MarjaKarolinska Institutet (author)
Hagenfeldt, KerstinKarolinska Institutet (author)
Nordenskjöld, AgnetaKarolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

Related titles

In:The Journal of clinical endocrinology and metabolism: The Endocrine Society95:8, s. 3633-401945-71970021-972X

Internet link

Find in a library

The Journal of clinical endocrinology and metabolism (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Nordenström, Ann ...; Frisén, Louise; Falhammar, Henri ...; Filipsson, Helen ...; Holmdahl, Gundel ...; Janson, Per-Olof ...; show more...; Thorén, Marja; Hagenfeldt, Kers ...; Nordenskjöld, Ag ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

Articles in the publication: The Journal of c ...

By the university: University of Gothenburg; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se