Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment

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O'Neil, Serena,1981Gothenburg University,Göteborgs universitet,Krefting Research Centre (author)

Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment

Article/chapterEnglish2010

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2010-11-02
Springer Science and Business Media LLC,2010

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LIBRIS-ID:oai:gup.ub.gu.se/129873
https://gup.ub.gu.se/publication/129873URI
https://doi.org/10.1186/1710-1492-6-28DOI

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Language:English

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Subject category:art swepub-publicationtype

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Abstract Background Osteopontin (OPN) is a multifunctional cytokine that has been primarily investigated in Th1 diseases. Recently, it has also been implicated in Th2-mediated allergic diseases, such as asthma. The expression of OPN in allergic rhinitis (AR) is currently unknown, as is the effect of intranasal glucocorticosteroids (GCs) on that expression. Methods Subjects with AR were randomised to receive treatment with fluticasone propionate (FP) (n = 12) or a placebo (n = 16) over the grass pollen season and nasal biopsies were taken prior to, and during the season. OPN expression in the nasal mucosa was examined with immunohistochemistry. Healthy non-AR controls (n = 5) were used as a comparator. Results OPN expression was detected in epithelial cells, subepithelial infiltrating/inflammatory cells and cells lining the vessels and glands of all subjects. Comparison of the pre- and peak-pollen season biopsy sections in placebo treated patients revealed no increase in OPN expression during the grass pollen season (5.7% vs 6.4%). Treatment with a local glucocorticosteroid did not alter the expression of OPN during pollen exposure (6.2% vs 6.7%). Conclusion OPN has been increasingly associated with the pathogenesis of various Th2-mediated diseases. However, our finding that the OPN expression in the nasal mucosa of AR patients is not significantly affected by allergen exposure and is comparable to that of the healthy controls, suggests that intracellular OPN is not directly involved in the pathogenesis of allergic rhinitis.

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Malmhäll, Carina,1959Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xmalmc (author)
Samitas, Konstantinos,1977Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xsamko (author)
Pullerits, Teet,1967Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xpullt (author)
Bossios, Apostolos,1969Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xbosap (author)
Lötvall, Jan,1956Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xlotja (author)
Göteborgs universitetKrefting Research Centre (creator_code:org_t)

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In:Allergy, Asthma & Clinical Immunology: Springer Science and Business Media LLC6:11710-1492

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