Serum leptin levels in patients undergoing carotid endarterectomy: a pilot study.

• INTRODUCTION: Elevated serum leptin levels are associated with cardiovascular events. We investigated the role of serum leptin in patients undergoing carotid endarterectomy (CEA). METHODS: A total of 74 patients (55 men; 38 symptomatic and 36 asymptomatic; mean age 66.9 +/- 8.2 years) undergoing CEA for >70% carotid artery stenosis were enrolled. RESULTS: Serum leptin levels were lower in symptomatic compared with asymptomatic patients (7.1 +/- 1.3 vs 14.4 +/- 4.7 ng/dL; P < .001). Interleukin-6 (IL-6) levels were higher in symptomatic compared with asymptomatic patients (4.3 +/- 1.7 vs 3.3 +/- 1.1 pg/dL; P = .017). Symptomatic patients had more intense macrophage accumulation (0.7% +/- 0.1% vs 0.3% +/- 0.1%; P < .001). Serum leptin and serum IL-6 levels were independently associated with the presence of symptoms in multivariate analysis. CONCLUSION: Serum leptin levels were decreased in symptomatic carotid artery disease. This finding requires further investigation in larger studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Aged

Aged

80 and over

Biological Markers

blood

Body Mass Index

Carotid Artery Diseases

blood

surgery

Disease Progression

Endarterectomy

Carotid

methods

Enzyme-Linked Immunosorbent Assay

Female

Follow-Up Studies

Humans

Interleukin-6

blood

Leptin

blood

Male

Middle Aged

Nephelometry and Turbidimetry

Pilot Projects

Prognosis

Risk Factors

Treatment Outcome

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)