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  • Xu, Jianfeng (författare)

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • 2010-01-11
  • Proceedings of the National Academy of Sciences,2010

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/130910
  • https://gup.ub.gu.se/publication/130910URI
  • https://doi.org/10.1073/pnas.0914061107DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32699URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:120011220URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is urgently needed to reduce overdiagnosis and overtreatment of this common disease. To search for such factors, we compared the frequencies of SNPs among PCa patients who were defined as having either more aggressive or less aggressive disease in four populations examined in the Genetic Markers of Susceptibility (CGEMS) study performed by the National Cancer Institute. SNPs showing possible associations with disease severity were further evaluated in an additional three independent study populations from the United States and Sweden. In total, we studied 4,829 and 12,205 patients with more and less aggressive disease, respectively. We found that the frequency of the TT genotype of SNP rs4054823 at 17p12 was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied, with an overall P value of 2.1 x 10(-8) under a recessive model, exceeding the conservative genome-wide significance level. The difference in frequency was largest between patients with high-grade, non-organ-confined disease compared with those with low-grade, organ-confined disease. This study demonstrates that inherited variants predisposing to aggressive but not indolent PCa exist in the genome, and suggests that the clinical potential of such variants as potential early markers for risk of aggressive PCa should be evaluated.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zheng, Siqun Lilly (författare)
  • Isaacs, Sarah D (författare)
  • Wiley, Kathleen E (författare)
  • Wiklund, FredrikKarolinska Institutet (författare)
  • Sun, Jielin (författare)
  • Kader, A Karim (författare)
  • Li, Ge (författare)
  • Purcell, Lina D (författare)
  • Kim, Seong-Tae (författare)
  • Hsu, Fang-Chi (författare)
  • Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (författare)
  • Hugosson, Jonas,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xhugjo (författare)
  • Adolfsson, JanKarolinska Institutet (författare)
  • Walsh, Patrick C (författare)
  • Trent, Jeffrey M (författare)
  • Duggan, David (författare)
  • Carpten, John (författare)
  • Grönberg, HenrikKarolinska Institutet (författare)
  • Isaacs, William B (författare)
  • Karolinska InstitutetUrologi och andrologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences107:5, s. 2136-401091-64900027-8424
  • Ingår i:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences107:5, s. 2136-400027-8424

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