Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?

• Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Adult

Age Factors

Antibodies

blood

Antiviral Agents

administration & dosage

Body Mass Index

Drug Therapy

Combination

Hepacivirus

genetics

Hepatitis C

blood

drug therapy

immunology

virology

Humans

Interferon Alfa-2a

administration & dosage

blood

immunology

Middle Aged

Multivariate Analysis

Polyethylene Glycols

administration & dosage

RNA

Viral

analysis

Ribavirin

administration & dosage

Viral Load

Publication and Content Type

ref (subject category)

art (subject category)